To use all functions of this page, please activate cookies in your browser.
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Additional recommended knowledge
Indels can be contrasted with a point mutation; where an Indel inserts or deletes nucleotides from a sequence, a point mutation is a form of substitution that replaces one of the nucleotides.
An "indel" change of a single DNA base encoding part of a mRNA results in a "frameshift" when translating the mRNA and perhaps reading on to an inappropriate (premature) stop codon in a different frame. Indels are uncommon in coding regions but common in non-coding regions.
The term "indel" has been co-opted in recent years by genome scientists for use in the sense described above. Note that this is a change from its original use and meaning, which arose from the systematics field, referring to differences between sequences, such as from two different species, in which it was impossible to infer if one species lost the sequence or the other species gained it. For example, species A has a run of 4 G nucleotides at a particular locus, but species B has 5 G's at the same locus. If the mode of selection is unknown, then it is equally plausible that species A could have lost one G (a "deletion" event") or species B could have gained the G (an "insertion" event). In cases where it is impossible to infer phylogenetic direction of the sequence change, the sequence change event will be referred to as an "indel".
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Indel". A list of authors is available in Wikipedia.|