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Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. It is one of the most frequently used blood plasma substitutes under the trade names Hespan by B. Braun Medical Inc. and Voluven by Fresenius Kabi. It is also used in oil drilling.
Additional recommended knowledge
An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood caused by trauma, surgery, or some other problem. It increases the blood volume, allowing red blood cells to continue to deliver oxygen to the body.
The elimination depends on molar substitution degree. Molecules smaller than the renal threshold (60–70 kDa) are readily excreted in the urine while the larger ones are metabolized by plasma α–amylase before the degradation products are renally excreted.
Anaphylactoid reactions: hypersensitivity, mild influenza-like symptoms, bradycardia, tachycardia, bronchospasm and non-cardiogenic pulmonary edema.
Decrease in hematocrit and disturbances in coagulation. May be associated with covering the use of anabolic steroids/EPO for endurance athletes.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Hydroxyethyl_starch". A list of authors is available in Wikipedia.|