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Howel-Evans syndrome

Howel-Evans syndrome
Classification & external resources
OMIM 148500
DiseasesDB 33404

Howel-Evans syndrome is an extremely rare condition in which the skin of the palms of the hands, and soles of the feet, are affected (hyperkeratosis). The effects on the palms and soles is called tylosis, and in Howel-Evans syndrome, there is a predisposition to oesophageal cancer, particularly squamous cell carcinoma.[1]

Howel-Evans syndrome was described in 1996 as being identical with palmoplantar ectodermal dysplasia type III.


The skin is treated with a keratolytic (such as salicylic acid) to dissolve the excess skin, and systemic treatment with retinoids (derivatives of Vitamin A) may be given.

See also

  • Palmoplantar keratoderma


  1. ^ HOWEL-EVANS W, McCONNELL RB, CLARKE CA, SHEPPARD PM (1958). "Carcinoma of the oesophagus with keratosis palmaris et plantaris (tylosis): a study of two families". Q. J. Med. 27 (107): 413–29. PMID 13579162.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Howel-Evans_syndrome". A list of authors is available in Wikipedia.
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