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HLA-DR8


human major histocompatibility complex, class II, DR8
Haplotypes groups	DQA01:DRB10801 to DQA01:DRB10806
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 0801 to 0806
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*0801
EBI-HLA	DRB1*0802
EBI-HLA	DRB1*0803
EBI-HLA	DRB1*0804
EBI-HLA	DRB1*0805
EBI-HLA	DRB1*0806
Shared data
Locus	chr.6 6p21.31

HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.

Serology

The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.

DQ8 is linked to papillary thyroid carcinomas ^[3], early onset pauciarticular juvenile chronic arthritis^[4]^[5], primary biliary cirrhosis^[6]

HLA-DRB1*0801 is linked to primary biliary cirrhosis^[7] In Mexicans DR8 is found more often in type-2 juvenile diabetes.^[8]

HLA-DRB1*0803 is also linked to primary biliary cirrhosis^[7]

HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.

^ derived from IMGT/HLA
^ DR12 - 3%
^ Porto T, Coelho I, Boavida J, Pereira C, Nunes J, Mendonça D, Martins B, Sobrinho L, Leite V (2006). "Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas.". Clin Endocrinol (Oxf) 64 (2): 179-83. PMID 16430717.
^ Haas J, Truckenbrodt H, Paul C, Hoza J, Scholz S, Albert E. "Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis.". Clin Exp Rheumatol 12 Suppl 10: S7-14. PMID 7955632.
^ Säilä H, Pitkäniemi J, Tuomilehto J, Savolainen A, Alakulppi N, Tuomilehto-Wolf E, Leirisalo-Repo M, Aho K (2004). "HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population.". J Rheumatol 31 (11): 2281-5. PMID 15517645.
^ Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R (1992). "Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype.". Hepatology 16 (6): 1404-8. PMID 1359995.
^ ^a ^b Charatcharoenwitthaya P, Lindor K. "Current concepts in the pathogenesis of primary biliary cirrhosis.". Ann Hepatol 4 (3): 161-75. PMID 16177655.
^ Rodríguez-Ventura AL, Yamamoto-Furusho JK, Coyote N, et al (2007). "HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children". Pediatric diabetes 8 (1): 5-10. doi:10.1111/j.1399-5448.2006.00221.x. PMID 17341285.

v • d • e HLA DR Serotypes
DR - DR1 - DR2 - DR3 - DR4 - DR5 - DR6 - DR7 - DR8 - DR9 - DR10 - DR11 - DR12 - DR13 - DR14 - DR15 - DR16 - DR17 - DR18 - DR51 - DR52 - DR53

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-DR8". A list of authors is available in Wikipedia.

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