|
|
| major histocompatibility complex, class II, DR15
|
| Haplotypes groups
| DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507
|
| Structure (See HLA-DR)
|
| Identifiers | alpha *0101
|
| Symbol(s)
| HLA-DRA
|
| EBI-HLA
| DRA*0101
|
| Identifiers | beta 1 *1501 to *1505 *1507
|
| Symbol(s)
| HLA-DRB1
|
| EBI-HLA
| DRB1*1501
|
| EBI-HLA
| DRB1*1502
|
| EBI-HLA
| DRB1*1503
|
| EBI-HLA
| DRB1*1504
|
| EBI-HLA
| DRB1*1505
|
| EBI-HLA
| DRB1*1507
|
| Shared data
|
| Locus
| chr.6 6p21.31
|
HLA-DR15(DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.
Additional recommended knowledge
Serology
DR15, DR2 and other serotype recognition of some DRB1*15 alleles[1]
| DRB1* | DR15
| DR2 | DR16 | Sample
|
| allele | % | % | % | size (N)
|
| 1501 | 76 | 23 | | 6428
|
| 1502 | 77 | 16 | | 676
|
| 1503 | 81 | 13 | | 286
|
| 1504 | >50 | | | 1
|
| 1505 | >25 | | | 2
|
| 1507 | >50 | | | 1
|
Serotypes are unknown the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522.
DRB1*1517N is a null.
Alleles
Disease associations
DR15 is positively associated goodpasture syndrome[2], early age onset multiple sclerosis[3], pernicious anaemia,[4] sarcoidosis,[5] and a predisposition for postmenopausal osteoporosis.[6]
DRB1*1501 is positively associated with Goodpasture syndrome[7][8], juvenile rheumatoid arthritis[9], allergic bronchopulmonary aspergillosis[10], multiple sclerosis[11], systemic lupus erythematosus[12], cervical cancer (human papillomavirus infection)[13], and Sjogren's syndrome associated with systemic lupus erythematosus.[14]
DRB1*1502 is associated with systemic lupus erythematosus[15], systemic sclerosis (SSc) & anti-topoisomerase antibodies.[16]
DRB1*1503 is associated with Chaga's cardiomyopathy[17], allergic bronchopulmonary aspergillosis[18], multiple sclerosis[11], cervical cancer (human papillomavirus infection).[19]
Extended linkage
DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)[19]
DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus[15]
Genetic Linkage
| DR15 Haplotypes
|
| Serotypes
| DRA | DRB1 | DRB5
|
| DR15(2)-DR51
| *0101 | *1501 | *0101
|
| *0101 | *1502 | *0101
|
| *0101 | *1503 | *0101
|
| *0101 | *1504 | *0101
|
| *0101 | *1505 | *0101
|
| *0101 | *1507 | *0101
|
|
| DQA1 | DQB1 | DRB1
|
| DR15(2)-DQ6(6.2, 1)
| *0102 | *0602 | *1501
|
| DR15(2)-DQ6(6.1, 1)
| *0103 | *0601 | *1502
|
|
| HLA-A | HLA-B | DRB1
|
| A3-Cw7-B7-DR15(2)
| *0301 | *0702 | *1501
|
| A1-B51-DR15(2)
| *0101 | *5101 | *1502
|
HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.
References
- ^ derived from IMGT/HLA
- ^ Phelps R, Jones V, Turner A, Rees A (2000). "Properties of HLA class II molecules divergently associated with Goodpasture's disease.". Int Immunol 12 (8): 1135-43. PMID 10917888.
- ^ Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J (2000). "HLA-DR15 is associated with lower age at onset in multiple sclerosis.". Ann Neurol 48 (2): 211-9. PMID 10939572.
- ^ Ungar B, Mathews J, Tait B, Cowling D (1981). "HLA-DR patterns in pernicious anaemia.". Br Med J (Clin Res Ed) 282 (6266): 768-70. PMID 6783164.
- ^ Bilir M, Sipahi S, Yilmaz E, et al (2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356-9. PMID 17458393.
- ^ Douroudis K, Tarassi K, Athanassiades T, et al (2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens 69 (6): 592-6. doi:10.1111/j.1399-0039.2007.00833.x. PMID 17498269.
- ^ Robertson J, Wu J, Arends J, Glass W, Southwood S, Sette A, Lou Y (2005). "Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis.". Kidney Int 68 (3): 1061-70. PMID 16105036.
- ^ Phelps R, Rees A (1999). "The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity.". Kidney Int 56 (5): 1638-53. PMID 10571772.
- ^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.". Hum Immunol 65 (4): 359-65. PMID 15120191.
- ^ Slavin R, Hutcheson P, Chauhan B, Bellone C. "An overview of allergic bronchopulmonary aspergillosis with some new insights.". Allergy Asthma Proc 25 (6): 395-9. PMID 15709450.
- ^ a b Quelvennec E, Bera O, Cabre P, Alizadeh M, Smadja D, Jugde F, Edan G, Semana G (2003). "Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome.". Tissue Antigens 61 (2): 166-71. PMID 12694585.
- ^ Takeuchi F, Nakano K, Nabeta H, Hong G, Kawasugi K, Mori M, Okudaira H, Kuwata S, Tanimoto K (2005). "Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients.". Int J Immunogenet 32 (3): 173-8. PMID 15932622.
- ^ Apple R, Erlich H, Klitz W, Manos M, Becker T, Wheeler C (1994). "HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity.". Nat Genet 6 (2): 157-62. PMID 8162070.
- ^ Manoussakis M, Georgopoulou C, Zintzaras E, Spyropoulou M, Stavropoulou A, Skopouli F, Moutsopoulos H (2004). "Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome.". Arthritis Rheum 50 (3): 882-91. PMID 15022331.
- ^ a b Sirikong M, Tsuchiya N, Chandanayingyong D, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K (2002). "Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais.". Tissue Antigens 59 (2): 113-7. PMID 12028537.
- ^ Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody.". Arthritis Rheum 42 (3): 465-74. PMID 10088769.
- ^ García Borrás S, Diez C, Cotorruelo C, Pellizon O, Biondi C, Beloscar J, Bottasso O, Racca A (2006). "HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection.". Ann Clin Biochem 43 (Pt 3): 214-6. PMID 16704757.
- ^ Slavin R, Hutcheson P, Chauhan B, Bellone C. "An overview of allergic bronchopulmonary aspergillosis with some new insights.". Allergy Asthma Proc 25 (6): 395-9. PMID 15709450.
- ^ a b Maciag P, Schlecht N, Souza P, Franco E, Villa L, Petzl-Erler M (2000). "Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women.". Cancer Epidemiol Biomarkers Prev 9 (11): 1183-91. PMID 11097225.
|
