My watch list
my.bionity.com  
Login  

Gray baby syndrome



Gray baby syndrome
Classification & external resources
ICD-10 P93.
ICD-9 779.4
MedlinePlus 007049

Gray baby syndrome (also termed Gray or Grey syndrome) is a rare but serious side effect that occurs in newborn infants (especially premature babies) following the intravenous administration of the antibiotic chloramphenicol.[1]

Additional recommended knowledge

Contents

Pathophysiology

Newborn infants are predisposed to this condition because they do not yet have fully functional liver enzymes, nor do they have enough enzymes to handle the drug.[2]

Clinical features

Toxic levels of chloramphenicol after 2–9 days result in:

Treatment

Chloramphenicol therapy is discontinued immediately; exchange transfusion may be required to remove the drug.

Prevention

The condition can be prevented by using chloramphenicol at the recommended doses and monitoring blood levels.[3][4][5]

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Gray_baby_syndrome". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE