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Gray baby syndrome

Gray baby syndrome
Classification & external resources
ICD-10 P93.
ICD-9 779.4
MedlinePlus 007049

Gray baby syndrome (also termed Gray or Grey syndrome) is a rare but serious side effect that occurs in newborn infants (especially premature babies) following the intravenous administration of the antibiotic chloramphenicol.[1]



Newborn infants are predisposed to this condition because they do not yet have fully functional liver enzymes, nor do they have enough enzymes to handle the drug.[2]

Clinical features

Toxic levels of chloramphenicol after 2–9 days result in:


Chloramphenicol therapy is discontinued immediately; exchange transfusion may be required to remove the drug.


The condition can be prevented by using chloramphenicol at the recommended doses and monitoring blood levels.[3][4][5]

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Gray_baby_syndrome". A list of authors is available in Wikipedia.
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