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In population genetics, genetic load or genetic burden is a measure of the cost of lost alleles due to selection (selectional load) or mutation (mutational load). It is a value in the range 0 < L < 1, where 0 represents no load. The concept was first formulated in 1937 by JBS Haldane, independently formulated, named and applied to humans in 1950 by H. J. Muller, and elaborated further by Haldane in 1957.
Additional recommended knowledge
Genetic load is the reduction in selective value for a population compared to what the population would have if all individuals had the most favored genotype. It is normally stated in terms of fitness as the reduction in the mean fitness for a population compared to the maximum fitness.
where wmax is the maximum value of the fitnesses and is mean fitness which is calculated as the mean of all the fitnesses weighted by their corresponding allele frequency:
where the ith allele is and has the fitness and frequency wi and pi respectively.
When the wmax = 1, then (1) simplifies to
Causes of genetic load
Load may be caused by selection and mutation.
Load caused by mutations is known as mutational load.
Selection occurs when the fitnesses of particular alleles are inequal, hence selection always exerts a load.
With directional selection, the allele frequencies will tend towards an equilibrium position with the fittest allele reaching a frequency in mutation-selection balance. As mutations are rare, this is effectively fixation. Consider two alleles and . If w1 > w2, then at equilibrium, and , hence , and .
If the mean fitness is 0, the load is equal to 1, but the population goes extinct.
In contrast to directional selection, heterozygote advantage always exerts a load at equilibrium.
Some creationists (such as Henry M. Morris) have suggested that mutational load would increase over time and thus make populations inviable. However, they ignore the effect of selectional load acting to weed out (decrease frequency of) deleterious mutations.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Genetic_load". A list of authors is available in Wikipedia.|