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Fibroblast growth factor
Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. The FGFs are heparin-binding proteins and interactions with cell-surface associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs are key-players in the processes of proliferation and differentiation of cells, particularly endothelial cells; they ( especially FGF-1) promote angiogenesis.
Additional recommended knowledge
The fibroblast growth factor receptor family consists of 4 members, FGFR1, FGFR2, FGFR3, and FGFR4.
Alternate mRNA splicing gives rise to multiple mRNA splice variants, of which the FGFR2IIIb splice variant encode isoform 2, the canonical FGF-10 receptor. 13 protein receptor isoforms are derived from the FGFR2 gene, e.ge., and the active sites differ significantly in their ligand-binding profiles.
The signaling complex at the cell surface is believed to be a ternary complex formed between two identical FGF ligands, two identical FGFR subunits and either one or two heparan (dermatan and/or chondroitin) sulfate chains.
They then further fractionated the extract using acidic and basic pH and isolated two slightly different forms that were named "acidic fibroblast growth factor" (FGF-1) and "basic fibroblast growth factor" (FGF-2). These proteins had a high degree of amino acid identity but were determined to be distinct mitogens. Human FGF-2 occurs in low molecular weight (LMW) and high molecular weight (HMW) isoforms. LMW FGF-2 is primarily cytoplasmic and functions in an autocrine manner, whereas HMW FGF-2s are nuclear and exert activities through an intracrine mechanism.
Not long after FGF-1 and FGF-2 were isolated, another group isolated a pair of heparin-binding growth factors which they named HBGF-1 and HBGF-2, whilst a third group isolated a pair of growth factors that caused proliferation of cells in a bioassay containing blood vessel endothelium cells which they called ECGF-1 and ECGF-2. These proteins were found to be identical to the acidic and basic FGFs described by Gospodarowicz and coworkers.
One of the most important functions of aFGF (FGF-1) and bFGF (FGF-2) is the promotion of endothelial cell proliferation and the physical organization of endothelial cells into tube-like structures. It thus promotes angiogenesis, the growth of new blood vessels from the pre-existing vasculature. aFGF is a more potent angiogenic factor than VEGF (vascular endothelial growth factor) or PDGF (platelet-derived growth factor). As well as stimulating blood vessel growth, aFGF and bFGF are important players in wound healing. They stimulate angiogenesis and the proliferation of fibroblasts that give rise to granulation tissue, which fills up a wound space/cavity early in the wound healing process.
It has also been demonstrated that fibroblast growth factors are associated with many developmental processes including mesoderm induction, antero-posterior patterning, neural induction, angiogenesis, axon extension and limb formation.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fibroblast_growth_factor". A list of authors is available in Wikipedia.|