My watch list  

Fetal trimethadione syndrome

Fetal trimethadione syndrome (also known as paramethadione syndrome, German syndrome, tridione syndrome, among others[1]) is a set of birth defects caused by the administration of the anticonvulsants trimethadione (also known as Tridione) or paramethadione to epileptic mothers during pregnancy.[2]

Fetal trimethadione syndrome is classified as a rare disease by the National Institute of Health's Office of Rare Diseases,[3] meaning it affects less than 200,000 individuals in the United States.[4]

The fetal loss rate while using trimethadione has been reported to be as high as 87%.[5]


Fetal trimethadione syndrome is characterized by the following major symptoms as a result of the teratogenic characteristics of trimethadione.[6][7]

  • Cranial and facial abnormalities which include; microcephaly, midfacial flattening, V-shaped eyebrows, and a short nose
  • Cardiovascular abnormalities
  • Absent kidney and ureter
  • Meningocele, a birth defect of the spine
  • Omphalocele, a birth defect where portions of the abdominal contents project into the umbilical cord
  • A delay in mental and physical development


  1. ^ Additional names include trimethadione embryopathy and trimethadione syndrome.
  2. ^ Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007
  3. ^ Fetal trimethadione syndrome on the ORD website. Retrieved January 2007
  4. ^ Rare Diseases Retrieved January 2007
  5. ^ Teratology and Drug Use During Pregnancy Retrieved January 2007
  6. ^ Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007
  7. ^ The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome Retrieved January 2007
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fetal_trimethadione_syndrome". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE