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FYVE domain



Early endosome antigen 1 (EEA1) dimer with lipids
FYVE zinc finger
Identifiers
Symbol FYVE
Pfam PF01363
InterPro IPR000306
SCOP 1vfy
OPM family 62
OPM protein 1vfy
Available PDB structures:

1dvpA:156-219 1vfyA:168-230 1jocB:1347-1411 1hyjA:1347-1411 1hyiA:1347-1411 1wfkA:2-59 1x4uA:349-411

FYVE zinc finger domain is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1.

Additional recommended knowledge

The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. FYVE domains bind Phosphatidylinositol 3-phosphate.

The FYVE finger is structural similarity to RING domain and PHD finger.

Human proteins containing this domain

ANKFY1; EEA1; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; FYCO1; HGS; MTMR3; MTMR4; PIP5K3; PLEKHF1; PLEKHF2; RUFY1; RUFY2; WDF3; WDFY1; WDFY2; WDFY3; ZFYVE1; ZFYVE16; ZFYVE19; ZFYVE20; ZFYVE21; ZFYVE26; ZFYVE27; ZFYVE28; ZFYVE9;

References

  • [1]. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. Stenmark H, Aasland R, Toh BH, D'Arrigo A; J Biol Chem 1996;271:24048-24054. PubMed
  • [2]. FYVE fingers bind PtdIns(3)P. Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R; Nature 1998;394:432-433. PubMed
  • [3]. FYVE-finger proteins - effectors of an inositol lipid. Stenmark H, Aasland R; J Cell Sci 1999;112:4175-4183. PubMed
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "FYVE_domain". A list of authors is available in Wikipedia.
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