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Systematic (IUPAC) name
N,N-dimethyl-2- (1-phenyl-1-pyridin-2-yl-ethoxy)- ethanamine
CAS number 469-21-6
ATC code R06AA09
PubChem 3162
DrugBank APRD00937
Chemical data
Formula C17H22N2O 
Mol. mass 270.369 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life variable; 6–12 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status


Routes Oral

Doxylamine succinate is one of the many sedating antihistamines used by itself as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug, and a preparation is prescribed in combination with vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.


Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power superior to almost every other antihistamine on the market, with the exception of diphenhydramine (Benadryl).[citation needed] It is also the most effective over-the-counter sedative available in the United States[citation needed], and more sedating than some prescription hypnotics. In a study, it was found that doxylamine succinate is possibly more effective than the barbiturate phenobarbital for use as a sedative.[citation needed] For this reason, doxylamine has sometimes been used off label in a manner similar to diphenhydramine for the reduction of anxiety symptoms.

The dosage required to induce hypnosis (sleep) can be as low as 6.25 mg, but is usually effective in dosages of up to 25 mg. Higher doses are not recommended by the United States Food and Drug Administration, although single dosage recommendations of up to 50 mg are common in countries like Australia, where it is marketed under the names Restavit and Dozile.


  • It is one of the active ingredients in NyQuil.
  • In Commonwealth countries, such as Australia, Canada, and the United Kingdom, doxylamine is available prepared with paracetamol (acetaminophen), codeine, and caffeine under the brand name Syndol or Mersyndol, as treatment for tension headache and other types of pain.
  • Doxylamine succinate is used in general over-the-counter sleep-aids branded as Somnil, DSozile, Restavit and Unisom-2.
  • In the United States doxylamine succinate is the active ingredient in the over-the-counter sleep-aid tablets branded as Unisom; however, according to the manufacturer's website, the gel-cap form contains diphenhydramine hydrochloride instead.
  • It is also available in combination with vitamin B6 and folic acid under the brand name Evanorm (marketed by Ion Healthcare).
  • In Canada, doxylamine succinate and pyridoxine (vitamin B6) are the ingredients of Diclectin, which is used to prevent morning sickness.

Side effects

Doxylamine succinate is a potent anticholinergic and has a side-effect profile common to such drugs, including dry mouth, ataxia, urinary retention, and drowsiness. Other drugs with well known anticholinergic effects include many antipsychotic and tricyclic antidepressant drugs.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Doxylamine". A list of authors is available in Wikipedia.
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