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Dihydrobiopterin is a compound produced in the synthesis of dopamine, norepinephrine and epinephrine through production of the intermediate 3,4-dihydroxy phenylalanine, also known as dopa. phenylalanine is converted into dopa using tetrahydrobiopterin releasing dihydrobiopterin and water, which is then converted back into tetrahydrobiopterin using the NADPH-dependent enzyme dihydrobiopterin reductase. This enzyme is sometimes defective in patients with phenylketonuria, and is treated in the same fashion, with tyrosine supplements and a controlled diet which is lacking in phenylalanine.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dihydrobiopterin_reductase". A list of authors is available in Wikipedia.|