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Diglyceride acyltransferase

diacylglycerol O-acyltransferase homolog 1 (mouse)
Symbol DGAT1
Entrez 8694
HUGO 2843
OMIM 604900
RefSeq NM_012079
UniProt O75907
Other data
EC number
Locus Chr. 8 q24.3
diacylglycerol O-acyltransferase homolog 2 (mouse)
Symbol DGAT2
Entrez 84649
HUGO 16940
OMIM 606983
RefSeq NM_032564
UniProt Q96PD7
Other data
Locus Chr. 11 q13.3

Diglyceride acyltransferase (or O-acyltransferase), DGAT, catalyzes the formation of triglycerides from diacylglycerol and Acyl-CoA. There are two isoforms of DGAT encoded by the genes DGAT1 and DGAT2. DGAT is considered the terminal and only committed step in triglyceride synthesis and to be essential for the formation of adipose tissue.[1] A number of pharmaceutical companies currently have DGAT-1 inhibitors in clinical trials for the treatment of obesity.[2]


  1. ^ Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV (1998). "Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13018-23. PMID 9789033.
  2. ^ Pfizer, Bristol finalize deal on metabolic drugs. Retrieved on 2007-08-27.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Diglyceride_acyltransferase". A list of authors is available in Wikipedia.
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