Corwin Hansch

Corwin Hansch (born October 6, 1918, Kenmare, North Dakota) is Professor Emeritus of Chemistry at Pomona College in California. He earned a B.S. from the University of Illinois in 1940 and a Ph.D. from New York University in 1944.

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Hansch may be best known as the father of the concept of quantitative structure-activity relationship (QSAR), the quantitative correlation of the physicochemical properties of molecules with their biological activities.

He is also noted for the Hansch equation, which is used in

• Multivariate Statistics - Multivariate statistics is a set of statistical tools to analyse data (e.g., chemical and biological) matrices using regression and/or pattern recognition techniques.

• Hansch Analysis - Hansch analysis is the investigation of the quantitative relationship between the biological activity of a series of compounds and their physicochemical substituent or global parameters representing hydrophobic, electronic, steric and other effects using multiple regression correlation methodology.

• Hansch-Fujita π constant - The Hansch-Fujita π constant describes the contribution of a substituent to the lipophilicity of a compound.

Research Interests: Organic Chemistry; Interaction of organic chemicals with living organisms, Quantitative Structure Activity Relationships (QSAR).

• Fragment based regression analysis for quantitative structure-activity relationship (Hansch-analysis)

See also

• Hammett equation
• Craig plot

References

• Book: Exploring QSAR - Corwin Hansch, Albert Leo and David Hoekman