Chlamydia muridarum

Chlamydia muridarum is an intracellular bacterial species that at one time belonged to Chlamydia trachomatis. However, C. trachomatis naturally only infects humans and C. muridarum naturally infects only members of the family Muridae (includes both mice and hamsters, Alderton, 1996).

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Two strains of Chlamydia muridarum, MoPn (originally named Nigg) and SFPD ^[1], have been isolated from mice and hamsters. Glycogen production by both strains has been demonstrated, although it is difficult to detect glycogen in MoPn (Moulder et al., 1984). The chromosome and extrachromosomal plasmid of MoPn have been sequenced.

Chlamydia muridarum MoPn binds mAbs recognizing Chlamydia trachomatis MOMP vs4 core epitope (T)LNPT(IA) ^[2]. DNA sequence analysis indicates that these mAbs should recognize SFPD and that Chlamydia trachomatis B-serogroup mAbs speci.c for the vs4 epitope IAGAG should recognize SFPD ^[3]. MoPn was isolated in 1942 from the lungs of asymptomatic albino Swiss mice and was subsequently shown to be capable of producing disease in mice ^[4]. SFPD was obtained from a hamster, concurrent with a causative agent of proliferative ileitis. MoPn has been shown to be sensitive to sulfadiazine.

References

1. ^ Fox et al., 1993; Nigg, 1942; Stills et al., 1991
2. ^ Peterson et al., 1991
3. ^ Batteiger et al., 1996
4. ^ Nigg, 1942