My watch list
my.bionity.com  
Login  

Channelrhodopsin



Channelrhodopsins are light-gated ion channels. They are useful molecules, enabling the use of light to control intracellular acidity, calcium influx, and electrical excitability.

Additional recommended knowledge

Two channelrhodopsins are currently known: Channelrhodopsin-1 and Channelrhodopsin-2 are both light gated proton channels, but Channelrhodopsin-2 exhibits in addition some conductance for cations. Both proteins serve as sensory photoreceptors in the green alga Chlamydomonas controlling behavioural responses like photophobic and phototaxic responses at high light intensities.

Structurally, channelrhodopsins are retinylidene proteins. They are thought to be seven-transmembrane proteins like rhodopsin, and contain the light-isomerizable vitamin A derivative all-trans-retinal. However, whereas most opsins are G-protein coupled receptors that open other ion channels indirectly via messengers, channelrhodopsins form a channel pore itself. This makes cellular depolarization extremely fast, robust, and useful for bioengineering and neuroscience applications, including photostimulation. Peak absorbance of the Channelrhodopsin-2 retinal complex is about 460 nm. Channelrhodopsin-2 and the yellow light-activated chloride pump halorhodopsin together enable multiple-color optical activation and silencing of neural activity.

External links

  • Optogenetics Resource Center
  • Using channelrhodopsin to optically activate neurons
  • Using channelrhodopsin potentially to treat blindness
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Channelrhodopsin". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE