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CTGF




Connective tissue growth factor
Identifiers
Symbol(s) CTGF; CCN2; HCS24; IGFBP8; MGC102839; NOV2
External IDs OMIM: 121009 MGI: 95537 Homologene: 1431
RNA expression pattern

Additional recommended knowledge

More reference expression data

Orthologs
Human Mouse
Entrez 1490 14219
Ensembl ENSG00000118523 ENSMUSG00000019997
Uniprot P29279 Q91V29
Refseq NM_001901 (mRNA)
NP_001892 (protein)
NM_010217 (mRNA)
NP_034347 (protein)
Location Chr 6: 132.31 - 132.31 Mb Chr 10: 24.28 - 24.29 Mb
Pubmed search [1] [2]

CTGF (connective tissue growth factor) is a cysteine-rich, matrix-associated, heparin-binding protein. In vitro, CTGF mirrors some of the effects of TGF beta on skin fibroblasts, such as stimulation of extracellular matrix production, chemotaxis, proliferation and integrin expression. CTGF can promote endothelial cell growth, migration, adhesion and survival and is thus implicated in endothelial cell function and angiogenesis[1].

CTGF binds to perlecan[2], a proteoglycan which has been localised in synovium, cartilage and numerous other tissues.

CTGF has been implicated in extracellular matrix remodelling in wound healing, scleroderma and other fibrotic processes, as it is capable of upregulating both matrix metalloproteinases (MMPs) and their inhibitors (TIMPs). Therefore, CTGF has the potential to activate both the synthesis and degradation of the extracellular matrix.

Knockout mice which have had the gene for CTGF removed do not develop normally. Impaired chondrocyte proliferation, angiogenesis, extracellular matrix production and turnover leads to abnormal skeletal growth.[3]

References

  1. ^ Brigstock DR (2002) Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis 5:153-165.
  2. ^ Nishida T et al. (2003) CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes. J Cell Physiol 196:265-275.
  3. ^ Ivkovic S et al. (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal deveopment Development 130:2779-2791.

Further reading

  • Brigstock DR (1999). "The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.". Endocr. Rev. 20 (2): 189-206. PMID 10204117.
  • Abdel Wahab N, Mason RM (2004). "Connective tissue growth factor and renal diseases: some answers, more questions.". Curr. Opin. Nephrol. Hypertens. 13 (1): 53-8. PMID 15090860.
  • Leask A (2004). "Transcriptional profiling of the scleroderma fibroblast reveals a potential role for connective tissue growth factor (CTGF) in pathological fibrosis.". The Keio journal of medicine 53 (2): 74-7. PMID 15247510.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CTGF". A list of authors is available in Wikipedia.
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