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CDGSH iron sulfur domain

Crystallographic structure (PDB 2QH7) of the CDGSH-type domain 1 dimer (green and cyan cartoon) complexed with iron (brown) and sulfur (yellow) Fe-S clusters.
CDGSH iron sulfur domain 1
Symbol CISD1
Alt. Symbols C10orf70, ZCD1
Entrez 55847
HUGO 30880
RefSeq NM_018464
UniProt Q9NZ45
Other data
Locus Chr. 10 q21.3
CDGSH iron sulfur domain 1B
Symbol CISD1B
Alt. Symbols ZCD1B
Entrez 130500
HUGO 29611
RefSeq XM_065750
Other data
Locus Chr. 2 p24.1
CDGSH iron sulfur domain 2
Symbol CISD2
Alt. Symbols ZCD2
Entrez 493856
HUGO 24212
RefSeq NM_001008388
UniProt Q7Z3D5
Other data
Locus Chr. 4 q24
CDGSH iron sulfur domain 3
Symbol CISD3
Entrez 284106
HUGO 27578
Other data
Locus Chr. 17 q12

The CDGSH iron sulfur domain are a group of iron-sulfur (Fe-S) clusters and a unique 39 amino acid CDGSH domain [C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H].

The CDGSH iron sulfur domain 1 protein (also referred to as mitoNEET) is an integral membrane protein located in the outer mitochondrial membrane and whose function may be to transport iron into the mitochondria.[1] Iron in turn is essential for the function of several mitochondrial enzymes.

The antidiabetic drug pioglitazone, in addition to binding to the nuclear receptor PPAR, also has been shown to bind mitoNEET with approximately equal affinity.[2]


  1. ^ Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA (2007). "MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone". Proc. Natl. Acad. Sci. U.S.A. 104 (36): 14342-7. doi:10.1073/pnas.0707189104. PMID 17766440.
  2. ^ Colca JR, McDonald WG, Waldon DJ, Leone JW, Lull JM, Bannow CA, Lund ET, Mathews WR (2004). "Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe". Am. J. Physiol. Endocrinol. Metab. 286 (2): E252-60. doi:10.1152/ajpendo.00424.2003. PMID 14570702.

External links

  • MeSH ZCD1+protein,+human
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CDGSH_iron_sulfur_domain". A list of authors is available in Wikipedia.
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