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Bufagins are a class of toxic steroids found as components of bufotoxin. They can be obtained (in form of marinobufagin, for example) from toad's milk, which refers to secretions from the Cane Toad (Bufo marinus), when it is injured, scared or provoked.
Additional recommended knowledge
Some bufagins have effects similar to poisoning by digitalis, having effects on the cardiac muscle, causing ventricular fibrillation. Some also have equally some local anesthetic action. The analgesic effects have also been proven, by acting as Na+/K+-ATPase inhibitors on the binding sites of the cell membrane. The anti-cancer properties in leukemia and melanoma cells, and the inhibition of the proliferation of prostate cancer cells, have also been investigated.
There are several closely related bufagins, including:
These bufagins, and especially cinobufagin, have given rise a large number of derivatives, such as desacetylcinobufagin 16-O-β-D-glucoside, 3-epi-desacetylcinobufagin 16-O-β-D-glucoside, 3-oxo-desacetylcinobufagin 16-O-β-D-glucoside and cinobufagin 3-O-β-D-glucoside.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bufagin". A list of authors is available in Wikipedia.|