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Apaf-1 (apoptotic protease activating factor 1) is a cytosolic protein involved in cell death or apoptosis. When Cytochrome c is released from the mitochondria, it interacts with Apaf-1 and dATP to form the apoptosome, a large oligomeric protein complex which can activate caspase 9.
Additional recommended knowledge
The crystal structure of this protein was solved in April of 2005 by the laboratory of Yigong Shi.
The actual mechanism for this reaction is still debated though work published in April of 2006 from the laboratory of Guy Salvesen suggests that the apoptosome may induce caspase 9 dimerization and subsequent autocatalyzation .
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Apaf-1". A list of authors is available in Wikipedia.|