My watch list  


Systematic (IUPAC) name
6-[3-(1-adamantyl)-4-methoxy-phenyl] naphthalene-2-carboxylic acid
CAS number 106685-40-9
ATC code D10AD03
PubChem 60164
DrugBank APRD00780
Chemical data
Formula C28H28O3 
Mol. mass 412.52 g/mol
Pharmacokinetic data
Bioavailability Very low
Metabolism  ?
Half life  ?
Excretion Biliary
Therapeutic considerations
Pregnancy cat.


Legal status

POM(UK) -only(US)

Routes Topical

Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.[1] It is currently marketed by Galderma under the trade names Differin® in some countries, and Adaferin® in India.



Adapalene is indicated for the topical treatment of acne vulgaris.

Adapalene has been shown to enhance the efficacity of topical clindamycin. Application of Adapalene gel to the skin 2-5 minutes before application of clindamycin enhances the overall efficacity of the treatment as compared to clindamycin alone


Adapalene was approved in 1996 by the U.S. Food and Drug Administration for use in the treatment of acne.


Adapalene is applied once daily, after washing and before retiring. In some circumstances, when a patient complains of skin irritation, this may be decreased to once every other day until the irritation ceases.

Available Forms

Differin is available in two forms, 0.1% adapalene and now the newer 0.3% adapalene (as of July 07)



Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. The exact mode of action of adapalene is unknown.


Adapalene is applied topically to the skin, and its absorption into the blood through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.


  1. ^ Rolewski S (2003). "Clinical review: topical retinoids.". Dermatol Nurs 15 (5): 447-50, 459-65. PMID 14619325.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Adapalene". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE