DNA Damage

News DNA Damage

• Coaxing cancer cells to commit suicide
  

  An LMU team has identified an enzyme that is essential for DNA repair. Loss of this factor leads to cell death when cancer cells accumulate DNA damage. Chemical inhibition of the target protein offers a possible strategy for the treatment of specific cancers. In Germany, as in most Western countries more

• Merck and Artios will conduct collaborative research
  

  Merck and Artios Pharma Limited, a leading DNA Damage Response (DDR) company developing a broad pipeline of precision medicines for the treatment of cancer, announced a global three year strategic research collaboration to discover and develop multiple precision oncology drugs. “Our platform has the more

• Research team discovers mechanism that restores cell function after genome damage
  

  A research team from Cologne has discovered that a change in the DNA structure – more precisely in the chromatin – plays a decisive role in the recovery phase after DNA damage. The key is a double occupation by two methyl groups on the DNA packaging protein histone H3 (H3K4me2). The discovery was ma more

Videos DNA Damage

ICR Researchers use Cryo-Electron Microscopy to zoom in on DNA code being read in cells

ICR Researchers led by Dr Alessandro Vannini have captured images of molecular machinery called RNA Polymerase III in the act of transcribing a gene in exquisite and unprecedented detail. Animation provided by Phospho Biomedical Animation more

Publications DNA Damage

• Electronic cigarette aerosols induce DNA damage and reduce DNA repair: Consistency across species [Biological Sciences]

  We read with great interest the work of Lee et al. (1), in which the authors report that mice exposed to electronic cigarette aerosol have increased levels of DNA lesions and decreased DNA repair activity. This work sparked important discussion both in PNAS (2, 3) and science media (4). We do share more

• Reply to Queimado et al.: E-cigarettes induce DNA damage and inhibit DNA repair in mice and human cells [Biological Sciences]

  We believe that Queimado et al. (1) may have inadvertently missed several key details presented in our recent PNAS publication (2). First, for the determination of nicotine effects on DNA adduct formation and DNA repair activity, the nicotine concentrations used for 1-h treatments of human lung and more

• Pharmacophore modeling, molecular docking and molecular dynamics simulations toward identifying lead compounds for Chk1

  Publication date: Available online 4 June 2018 Source:Computational Biology and Chemistry Author(s): Yaping Li, Jiale Peng, Yeheng Zhou, Penghua Li, Yingying Li, Xingyong Liu, Abu Nasar Siddique, Li Zhang, Zhili Zuo Checkpoint kinase 1 (Chk1), a serine/threonine protein kinas more