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t2cure is dedicated to the development of novel progenitor cell-based regenerative therapeutics to provide new treatment options to patients suffering from cardiovascular diseases like myocardial infarction or peripheral vascular diseases. more
After more than 40 years, several teams at the MDC and ECRC have now made a breakthrough discovery with the help of two animal models: they have proven that an altered gene encoding the enzyme PDE3A causes an inherited form of high blood pressure. This could lead to new concepts for the treatment of more
Short RNA molecules known as microRNAs (miRNAs) play a vital role in the regulation of gene expression. Anomalies in miRNAs expression and function have been implicated in pathological processes, such as the development of chronic diseases like atherosclerosis. The regulatory functions of miRNAs usu more
Polluted air is a public health hazard that cannot be evaded. It is widely known that long-term exposure to air pollution enhances the risks of cardiovascular and respiratory diseases. Scientists from the Max Planck Institute for Chemistry and the University Medical Center Mainz now calculated in a more
Experts in biomedical engineering and radiology have been awarded $15.5 million from the National Institutes of Health to build a PET scanner that could allow physicians to see inside the entire human body at once. Such a technology could have major implications for how cancer and other diseases ... more
Although congenital heart malformations are the most common birth defects in humans, the underlying pathomechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defect more
In all oxygen consuming cells, metabolism and oxidative stress generate several intermediates and byproducts that are collectively known as reactive oxygen species (ROS). ROS are necessary intermediates in the human body, but they are also involved i more
Up until the new millennium, the pharmaceutical industry grew stronger by 11%. However, the blockbuster model is increasingly at risk and the declining growth rates in the industry require a search for new strategies. In this context, orphan drugs ar more
Birth defects are the leading cause of infant mortality in the United States and Europe, with cardiac defects being the most prevalent. Here we define the requirement and mechanism of action of CHD4, the catalytic core component of the nucleosome remodeling and deacetylase (NuRD) complex, in embryon more
The U.S. National Institutes of Health (NIH) in Bethesda, Maryland, last week killed a huge clinical trial probing the potential benefits of moderate drinking after an investigation found that senior officials at the agency's alcohol institute secretly and improperly wooed the alcoholic beverage ind more
Marine Drugs, Vol. 16, Pages 216: Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend Enhances the Diversity of Gastrointestinal Microbiota Marine Drugs doi: 10.3390/md16060216 Authors: Erin K. Crowley Caitriona M. Long-Smith Amy Murphy Elaine Patterson Kiera Murphy more
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