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• Reading the human genome

  Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have achieved a major advance in understanding how genetic information is transcribed from DNA to RNA by providing the first step-by-step look at the biomolecular machinery that reads the huma more

• Moffitt researchers find potential new therapeutic target for treating non-small cell lung cancer

  Researchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer. It is based on the newly identified oncogene IKBKE, which helps regulate immune response. The study appeared in the online issue of Oncogene. The IKBKE gene i more

• Learning from the linker

  Mature cells can be reprogrammed to pluripotency and thus regain the ability to divide and differentiate into specialized cell types. Although these so-called induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, many of the biochemical processes that underlie repro more

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• Dual Luciferase Reporter (DLR) Assay Certification on the Omega Series of Readers
  

  The Dual-Luciferase® Reporter Assay or DLR is widely used to study gene transcription and regulation. The DLR assay is a two step reaction that uses two luciferase enzymes, Firefly and Renilla. The Firefly reaction is initiated, followed by its quenching and the subsequent initiation of the Renilla reaction. more

• Analysis of the DNA Methylation Patterns at the BRCA1 CpG Island
  

  Germ-line alterations of the BRCA1 gene confer a lifetime risk of 40% for ovarian cancers and of 40%-80% for ­breast cancers. It is likely that BRCA1 acts as a tumor suppressor gene. BRCA1 involvement in breast cancers does not seem to be restricted to familial cancers. Despite the absence of somatic mutations in the breast tissues, a down regulation of BRCA1 expression is associated with malignancy in human sporadic breast cancers. more

• Quantification of BRCA1 Expression Level Using Standard RT-PCR Reagents - a Sensitive Method for the Detection of Low Amounts of Transcripts
  

  Mutations in the breast cancer susceptibility gene, BRCA1, occur in the majority of families with multiple members affected with breast or ovarian cancer. Women who inherit a BRCA1 mutation have 40%-80% risk of developing breast cancer or ovarian cancer. However, up to 90% of breast cancers are sporadic, and mutations in BRCA1 seem to be a rare event in sporadic breast tumors. more

Publications Transcription

• Coevolution and Life Cycle Specialization of Plant Cell Wall Degrading Enzymes in a Hemibiotrophic Pathogen

  Zymoseptoria tritici is an important fungal pathogen on wheat that originated in the Fertile Crescent. Its closely related sister species Z. pseudotritici and Z. ardabiliae infect wild grasses in the same region. This recently emerged host–pathogen system provides a rare opportunity to investigate more

• The Evolution of the knirps Family of Transcription Factors in Arthropods

  The orphan nuclear receptor gene knirps and its relatives encode a small family of highly conserved proteins. We take advantage of the conservation of the family, using the recent prevalence of genomic data, to reconstruct its evolutionary history, identifying duplication events and tracing the int more

• Interspecific Divergence of Transcription Networks along Lines of Genetic Variance in Drosophila: Dimensionality, Evolvability, and Constraint

  Change in gene expression is a major facilitator of phenotypic evolution. Understanding the evolutionary potential of gene expression requires taking into account complex systems of regulatory networks, the structure of which could potentially bias evolutionary trajectories. We analyzed the evoluti more

Market studies Transcription

• MModal Inc. (MODL) - Financial and Strategic SWOT Analysis Review

  MModal Inc. (MODL) - Financial and Strategic SWOT Analysis Review Summary MModal Inc. (MModal), formerly MedQuist Holdings Inc., provides medical transcription software technology and services for clinical documentation workflow. The company offers its solutions and services to hospitals, health s more

• Medical Transcription Market in North America 2011-2015

  TechNavio's analysts forecast the Medical Transcription market in North America to grow at a CAGR of 4.7 percent in terms of revenue over the period 2011-2015. One of the key factors contributing to this market growth is the increasing demand for documentation procedures. The Medical Transcription m more

• Evolved Digital Systems Inc. - Strategic SWOT Analysis Review

  Evolved Digital Systems Inc. (Evolved Digital) is a healthcare technology solutions company, which specializes in delivering managed services of web-based digital imaging workflow solutions. The company’s range of managed services includes RadWeb, Data Verification, View, Disaster Recovery, Scheduli more

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