Insulin

News Insulin

• Novel study reports marijuana users have better blood sugar control

  Regular marijuana use is associated with favorable indices related to diabetic control, say investigators. They found that current marijuana users had significantly lower fasting insulin and were less likely to be insulin resistant, even after excluding patients with a diagnosis of diabetes mellitus more

• The criteria for weight-loss surgery need to be changed

  Weight-loss surgery is currently only offered to patients who exceed a certain BMI. However, surgical intervention could improve the health of many more people. This is shown by the Swedish Obese Subjects study carried out at the Sahlgrenska Academy, University of Gothenburg, Sweden, involving 104 p more

• Birth order linked to increased risk of diabetes, metabolic disorders

  Long a source of sibling rivalry, birth order may raise the risk of first-born children developing diabetes or high blood pressure. First-born children have greater difficulty absorbing sugars into the body and have higher daytime blood pressure than children who have older siblings, according to th more

White papers Insulin

• Rare Variants of IFIH1 Protect Against Type-1 Diabetes
  

  Nejentsev and co-workers have found that rare alleles of all associated IFIH1 polymorphisms consistently protect from type-1 diabetes, whereas IFIH1 alleles carried by the majority of the population predispose to the disease. This observation suggests that variants that disrupt IFIH1 function in the host antiviral response have been negatively selected rather than positively selected, because they confer protection from type-1 diabetes. Although the mechanisms by which IFIH1 polymorphisms contribute to type-1 diabetes pathogenesis remain to be explored, the authors noted that one of the protective variants is a non-sense mutation leading to a truncated 626-amino acid protein lacking the C-terminal helicase domain (Figure 1), whereas two other protective variants localize to the conserved splice donor sites and probably disrupt normal splicing of the IFIH1 transcript. This suggests that variants, which are predicted to reduce function of the IFIH1 protein, would decrease the risk of type-1 diabetes, whereas n more

• Evolutionary Link Between Maternal Behavior and Eusociality Is Supported by Wasp Gene Expression
  

  A defining feature of eusociality is the presence of workers that abstain from reproduction and care for their siblings (i.e., workers forage for food and feed the brood). It has been proposed that this behavior evolved from maternal care behavior and that sibling care and maternal care behaviors are regulated by similiar patterns of gene regulation. Toth et al. assessed this proposal by examining gene expression in the primitively eusocial wasp Polistes metricus using 454 Sequencing; 391,157 brain cDNA reads were generated and resulted in hits to 3,017 genes from the honey bee genome. Orthologs of 32 honey bee behaviorally related genes were identified and analyzed. The gene expression in the brain of P. metricus workers was more similar to that of foundresses, which show maternal care, than to that of queens and gynes, which do not. more

Publications Insulin

• Interspecific Divergence of Transcription Networks along Lines of Genetic Variance in Drosophila: Dimensionality, Evolvability, and Constraint

  Change in gene expression is a major facilitator of phenotypic evolution. Understanding the evolutionary potential of gene expression requires taking into account complex systems of regulatory networks, the structure of which could potentially bias evolutionary trajectories. We analyzed the evoluti more

• [Perspective] Cell Biology: Insulin Finds Its Niche

  Localized insulin signaling allows organ-specific rather than organism-level responses to the environmental conditions. more

• Microneedles for intradermal and transdermal drug delivery

  Publication date: Available online 13 May 2013 Source:European Journal of Pharmaceutical Sciences Author(s): Tuan-Mazlelaa Tuan-Mahmood , Maelíosa T.C. McCrudden , Barbara M. Torrisi , Emma McAlister , Martin J. Garland , Thakur Raghu Raj Singh , Ryan F. Donnelly The formidable barrier more

Market studies Insulin

• Insulin - Top 5 African Markets

  This market research report package offers an in-depth perspective on the actual market situation, trends and future outlook for insulin in top 5 African markets. The analyses provide essential market information for decision-makers including: Egypt, Nigeria, Morocco, Sudan and Ethiopia   * Overall more

• Insulin - Mongolia

  This market research report offers a perspective on the actual market situation, trends and future outlook for insulin in Mongolia. The study provides essential market information for decision-makers including: Overall market value for insulin in Mongolia Overall market volume for insulin i more

• Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020”. The report is an essential source of information and analysis on the global type 2 diabetes therapeutics market. The report provides comp more

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