Topic insulin

News insulin

• Dual strategy to fight Type 1 diabetes

  University of Florida researchers teamed with colleagues at City of Hope National Medical Center in Duarte, Calif., to devise a new combination therapy that reverses established Type 1 diabetes in mice. The findings, which appear in Science Translational Medicine, set the stage for the development o more

• Midatech and MonoSol Rx Announce Positive Phase 1 Clinical Results for their Novel Transbuccal Oral Insulin Film Product

  Midatech Ltd. and MonoSol Rx LLC announced positive bioavailability and pharmacokinetic results from a first-in-human Phase 1 clinical study of their Midaform™ Insulin PharmFilm product in 27 healthy volunteers. The companies have licensed to their joint venture company, MidaSol Therapeutics LLC, a more

• Stem cell researchers map new knowledge about insulin production

  Scientists from The Danish Stem Cell Center (DanStem) at the University of Copenhagen and Hagedorn Research Institute have gained new insight into the signaling paths that control the body's insulin production. This is important knowledge with respect to their final goal: the conversion of stem cell more

White papers insulin

• Rare Variants of IFIH1 Protect Against Type-1 Diabetes
  

  Nejentsev and co-workers have found that rare alleles of all associated IFIH1 polymorphisms consistently protect from type-1 diabetes, whereas IFIH1 alleles carried by the majority of the population predispose to the disease. This observation suggests that variants that disrupt IFIH1 function in the host antiviral response have been negatively selected rather than positively selected, because they confer protection from type-1 diabetes. Although the mechanisms by which IFIH1 polymorphisms contribute to type-1 diabetes pathogenesis remain to be explored, the authors noted that one of the protective variants is a non-sense mutation leading to a truncated 626-amino acid protein lacking the C-terminal helicase domain (Figure 1), whereas two other protective variants localize to the conserved splice donor sites and probably disrupt normal splicing of the IFIH1 transcript. This suggests that variants, which are predicted to reduce function of the IFIH1 protein, would decrease the risk of type-1 diabetes, whereas n more

• Evolutionary Link Between Maternal Behavior and Eusociality Is Supported by Wasp Gene Expression
  

  A defining feature of eusociality is the presence of workers that abstain from reproduction and care for their siblings (i.e., workers forage for food and feed the brood). It has been proposed that this behavior evolved from maternal care behavior and that sibling care and maternal care behaviors are regulated by similiar patterns of gene regulation. Toth et al. assessed this proposal by examining gene expression in the primitively eusocial wasp Polistes metricus using 454 Sequencing; 391,157 brain cDNA reads were generated and resulted in hits to 3,017 genes from the honey bee genome. Orthologs of 32 honey bee behaviorally related genes were identified and analyzed. The gene expression in the brain of P. metricus workers was more similar to that of foundresses, which show maternal care, than to that of queens and gynes, which do not. more

Publications insulin

• Improving cellular function and immune protection via layer‐by‐layer nanocoating of pancreatic islet β‐cell spheroids cocultured with mesenchymal stem cells

  Abstract Islet transplantation as a therapy for type 1 diabetes is currently limited by lack of primary transplant material from human donors and post‐transplantation loss of islets caused by adverse immune and nonimmune reactions. This study aimed to develop a novel strategy to create microenvir more

• Improving cellular function and immune protection via layer‐by‐layer nanocoating of pancreatic islet β‐cell spheroids cocultured with mesenchymal stem cells

  Abstract Islet transplantation as a therapy for type 1 diabetes is currently limited by lack of primary transplant material from human donors and post‐transplantation loss of islets caused by adverse immune and nonimmune reactions. This study aimed to develop a novel strategy to create microenvir more

• Differential expression of genes characterizing myofibre phenotype

  Summary Skeletal muscle is composed of metabolically heterogeneous myofibres that exhibit high plasticity at both the morphological and transcriptional levels. The objective of this study was to employ microarray analysis to elucidate the differential gene expression between the tonic‐‘red’ anter more

Market studies insulin

• Insulin - Top 5 African Markets

  This market research report package offers an in-depth perspective on the actual market situation, trends and future outlook for insulin in top 5 African markets. The analyses provide essential market information for decision-makers including: Egypt, Nigeria, Morocco, Sudan and Ethiopia   * Overall more

• Insulin - Mongolia

  This market research report offers a perspective on the actual market situation, trends and future outlook for insulin in Mongolia. The study provides essential market information for decision-makers including: Overall market value for insulin in Mongolia Overall market volume for insulin i more

• Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020”. The report is an essential source of information and analysis on the global type 2 diabetes therapeutics market. The report provides comp more

Websites insulin