Topic inhibitors

Companies inhibitors

Biomol GmbH, Germany

Biomol GmbH offers antibodies, enzymes, bioactive lipids, microarrays and reagents for biomedical research. Our focus is on cellular regulation and signal transduction. Together with our partners, we also provide a variety of specialized kits for drug discovery. more

News inhibitors

• Specificity by Ring Size

  New drug candidates require testing in animal models prior to approval for clinical use. A recently developed antagonist based on a bicyclic peptide inhibited the human serine protease plasma kallikrein potently and selectively. However, the inhibitor was ‘too’ selective, not inhibiting murine plasm more

• Ontochem and Priaxon Join Forces to Increase Stress Tolerance of Crops

  Ontochem GmbH and Priaxon AG announced the entry into a collaboration and commercialization agreement to obtain new superior inhibitors of the plant PARP, poly(ADP-ribose)polymerase enzyme. The goal of this collaboration is to increase the intrinsic stress tolerance of agricultural crops and accordi more

• Karyopharm Therapeutics Inc. and Katholieke Universiteit Leuven Sign Exclusive Collaboration for the Discovery of Novel CRM1/Exportin 1 Inhibitors

  Karyopharm Therapeutics Inc. has initiated an exclusive collaboration in the area of Selective Inhibitors of Nuclear Export (SINE) modulators of the CRM1 protein with the Rega Institute for Medical Research, a part of the Katholieke University of Leuven (K.U.Leuven), Belgium. The nuclear transport m more

White papers inhibitors

• Clinical Biomarkers: Novel Tools for Pharmacodynamic Applications
  

  Biomarkers are currently changing the way we diagnose and treat diseases. Today pharmacodynamic biomarkers are widely used in the industry elaborating optimal dosing of new drugs and predictive biomarkers have an enormous potential for companion diagnostics more

• RealTime ready RT-qPCR Assay Development and Qualification
  

  On the RealTime ready Configurator, we offer function tested human, mouse, and rat qPCR assays for gene expression quantification based on the unique Universal ProbeLibrary technology (UPL). The Universal ProbeLibrary is a set of short hydrolysis probes (8–9-mers) containing modified bases in order to stabilize the binding and thus ensure high flexibility together with good amplicon specificity more

• Expression Analysis of ABC Transporters in Lung Cancer Cell Lines Using a RealTime ready qPCR Focus Panel
  

  The novel small molecule inhibitors are often substrates of ABC transporters which influence the pharmacokinetic parameters of the drug candidates and cause drug resistance of tumor cells. Therefore expression profiling of ABC transporter genes in cell lines used for drug screening is highly important for anti-cancer drug discovery projects. Our purpose was to create a basic expression profile of ABC transporters in our mainly used lung cancer cell lines using the RealTime ready ABC Transporter Panel.The RealTime ready ABC-Transporter Panel comprises the 42 most important human ABC transporters in duplicate. The panel includes five controls for RNA quality and seven reference gene assays. The assays are supplied in a LightCycler® Instrument 480 Multiwell Plate 96 and contain target specific primers and a FAM-labeled Universal ProbLibrary hydrolysis probe that contains LNA more

Publications inhibitors

• Constitutive AhR activation leads to concomitant ABCG2‐mediated multidrug resistance in cisplatin‐resistant esophageal carcinoma cells

  Abstract Esophageal squamous cell carcinoma (ESCC) is a highly malignant disease that is generally not responding to chemotherapy. It is particularly predominant in China. Although ESCC is significantly associated with cigarette smoking, the relationship between its molecular pathogenesis and res more

• The use of high‐solids loadings in biomass pretreatment—a review

  Abstract The use of high‐solids loadings (≥15% solids, w/w) in the unit operations of lignocellulose conversion processes potentially offers many advantages over lower‐solids loadings, including increased sugar and ethanol concentrations and decreased production and capital costs. Since the term more

• Medication prescribing errors pertaining to cardiovascular/antidiabetic medications: a prescription audit in primary care

  Abstract This study was carried out to identify the medication prescribing errors (MPEs) pertaining to cardiovascular/antidiabetic medications in prescriptions issued to hypertensive and diabetic hypertensive patients. A retrospective, nationwide audit of prescriptions (n = 2773) issued by primar more

Market studies inhibitors

• Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020”. The report is an essential source of information and analysis on the global type 2 diabetes therapeutics market. The report provides comp more

• Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020”. The report is an essential source of information and analysis on the global ovarian cancer therapeutics market. The report provi more

• Men's Health Therapeutics Market to 2017 - Availability of Generic Sildenafil from 2012 to Restrain Market Growth

  GBI Research, the leading business intelligence provider, has released its latest research “Men's Health Therapeutics Market to 2017 - Availability of Generic Sildenafil from 2012 to Restrain Market Growth”. The report provides in-depth analysis of drivers and barriers that impact the global men’s h more

Websites inhibitors