Endothelin

News Endothelin

• Actelion submits a NDA for macitentan for the treatment of patients with pulmonary arterial hypertension

  Actelion announced that it has submitted a New Drug Application (NDA) to the US Food and Drug Administration (FDA) seeking approval for macitentan (Opsumit®) for the treatment of patients with pulmonary arterial hypertension.Macitentan, a novel oral dual endothelin receptor antagonist, was studied i more

• Abbott Announces Positive Results from Phase 2 Study of Low Dose Atrasentan for Treatment of Diabetic Kidney Disease

  Abbott announced positive results from a Phase 2 dose-ranging study of atrasentan, a highly selective endothelin A receptor antagonist in development to help slow chronic kidney disease (CKD) progression in patients with type 2 diabetic nephropathy (diabetic kidney disease). Study results suggest th more

• Key player identified in cascade that leads to hypertension-related kidney damage

  A key player in a cascade that likely begins with stress and leads to high blood pressure and kidney damage has been identified by researchers who say the finding may lead to better ways to control both. Medical College of Georgia researchers have found endothelin, a powerful blood vessel constricto more

Publications Endothelin

• Endothelin receptors in augmented vasoconstrictor responses to endothelin‐1 in chronic intermittent hypoxia

  Summary Chronic intermittent hypoxia (CIH) contributes to the development of cardiovascular diseases in patients with obstructive sleep apnoea. Many studies have shown an association between increased circulating endothelin (ET)‐1 levels and CIH. The aim of the present study was to determine t more

• The neuronal endopeptidase ECEL1 is associated with a distinct form of recessive distal arthrogryposis

  Distal arthrogryposis (DA) is a heterogeneous subgroup of arthrogryposis multiplex congenita (AMC), a large family of disorders characterized by multiple congenital joint limitations due to reduced fetal movements. DA is mainly characterized by contractures afflicting especially the distal extremit more

• Cerebral hypoperfusion in multiple sclerosis is reversible and mediated by endothelin-1 [Neuroscience]

  Decreased cerebral blood flow (CBF) may contribute to the pathology of multiple sclerosis (MS), but the underlying mechanism is unknown. We investigated whether the potent vasoconstrictor endothelin-1 (ET-1) is involved. We found that, compared with controls, plasma ET-1 levels in patients with MS w more

Market studies Endothelin

• R&D Trends: Prostate Cancer - Newly approved therapies shift treatment dynamics for castrate-resistant disease

  Introduction The late-phase prostate cancer pipeline is dominated by targeted therapies, closely followed by immunotherapies. There are a growing number of therapies with novel targets such as Zibotentan (AstraZeneca) which targets endothelin-A (ET-A). Identification of the correct molecular target more

• Endothelin A Receptor Antagonist (atrasentan) Fails to Demonstrate an Advantage in the Treatment of Advanced Prostate Cancer

  Introduction This year another endothelin A receptor antagonist failed to demonstrate an advantage for advanced prostate cancer. With the failure of atrasentan in Phase III followed by the failure of two Phase III trials of zibotentan, there is only one trial left which is exploring an endothelin a more

Websites Endothelin