Drug Resistance

News Drug Resistance

• Leopoldina makes recommendations for the G8 summit

  In the run up to the G8 summit in Lough Erne, Northern Ireland, the German National Academy of Sciences Leopoldina, in partnership with the national science academies of the G8 member states and five other science academies, is calling on the heads of state and government of the eight leading indust more

• Design help for drug cocktails

  For years, doctors treating those with HIV have recognized a relationship between how faithfully patients take the drugs they prescribe, and how likely the virus is to develop drug resistance. More recently, research has shown that the relationship between adherence to a drug regimen and resistance more

• Computational analysis identifies drugs to treat drug-resistant breast cancer

  Researchers have used computational analysis to identify a new Achilles heel for the treatment of drug-resistant breast cancer. The results, which are published in Molecular Systems Biology, reveal that the disruption of glucose metabolism is an effective therapeutic strategy for the treatment of tu more

White papers Drug Resistance

• Expression Analysis of ABC Transporters in Lung Cancer Cell Lines Using a RealTime ready qPCR Focus Panel
  

  The novel small molecule inhibitors are often substrates of ABC transporters which influence the pharmacokinetic parameters of the drug candidates and cause drug resistance of tumor cells. Therefore expression profiling of ABC transporter genes in cell lines used for drug screening is highly important for anti-cancer drug discovery projects. Our purpose was to create a basic expression profile of ABC transporters in our mainly used lung cancer cell lines using the RealTime ready ABC Transporter Panel.The RealTime ready ABC-Transporter Panel comprises the 42 most important human ABC transporters in duplicate. The panel includes five controls for RNA quality and seven reference gene assays. The assays are supplied in a LightCycler® Instrument 480 Multiwell Plate 96 and contain target specific primers and a FAM-labeled Universal ProbLibrary hydrolysis probe that contains LNA more

• Amplicon Sequencing with the GS FLX Titanium Series: High Sensitivity Targeted Resequencing
  

  Amplicon sequencing with the Genome Sequencer FLX System has already enabled a wide variety of scientific discoveries, particularly in clinical research. The introduction of the GS FLX Titanium Chemistry and the release of the associated amplicon sequencing protocols will continue to expand applications, as more and longer amplicons increase the depth of analysis for detecting rare variants and improve coverage of gene loci more

Publications Drug Resistance

• Kinetic Modeling–Based Detection of Genetic Signatures That Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network

  Drug resistance is a major cause of deaths from cancer. E2F1 is a transcription factor involved in cell proliferation, apoptosis. and metastasis through an intricate regulatory network, which includes other transcription factors like p73 and cancer-related microRNAs like miR-205. To investigate the more

• Evaluating the predictivity of virtual screening for Abl kinase inhibitors to hinder drug resistance

  Abstract Virtual screening (VS) methods are now widely used in early stages of drug discovery, aiming to rank potential inhibitors. However, any practical ligand set (of active or inactive compounds) chosen for deriving new VS approaches can not fully represent all relevant chemical space for po more

• Emergency room access for recurring seizures: when and why

  Background and purpose To develop a hypothetical model identifying potentially modifiable predictive factors of Emergency Room (ER) visits by patients suffering from drug resistant epilepsy. Methods During a 1‐year period, all adult drug resistant patients followed by the same epileptolog more

Market studies Drug Resistance

• Multi-Targeted Therapies - New Wave of Combination Therapies in Late Stage Development for Lung Cancer Offer Promise

  GBI Research, the leading business intelligence provider, has released its latest research, “Multi-Targeted Therapies - New Wave of Combination Therapies in Late Stage Development for Lung Cancer Offer Promise”, which provides an overview of the discovery and development of therapeutic drug combinat more

• Genesis Research and Development Corporation Limited (GEN) - Financial and Strategic SWOT Analysis Review

  Genesis Research and Development Corporation Ltd. (Genesis) is a publicly held NewZealand-based biotechnology company. The company is principally engaged in the development of therapeutics for the treatment of cancer and diseases of the immune system. It is completely focused on the development of t more

• Antibacterials Market to 2017 - Innovative Anti-Infectives that Target MDR Gram-Negative Pathogens Offer Significant Revenue Potential

  GBI Research, the leading business intelligence provider, has released its latest report, “Antibacterials Market to 2017 - Innovative Anti-Infectives that Target MDR Gram-Negative Pathogens Offer Significant Revenue Potential”, which provides key data, information and analysis for the global antibac more

Websites Drug Resistance