DNA Replication

News DNA Replication

• DNA damage: The dark side of respiration

  Adventitious changes in cellular DNA can endanger the whole organism, as they may lead to life-threatening illnesses like cancer. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich now report how byproducts of respiration cause mispairing of subunits in the double helix. The DNA in our c more

• How Alzheimer’s could occur
  

  A new hypothesis has been developed by researchers in Bochum on how Alzheimer’s disease could occur. They analysed the interaction of the proteins FE65 and BLM that regulate cell division. In the cell culture model, they discovered spherical structures in the nucleus that contained FE65 and BLM. The more

• Researchers at IRB Barcelona uncover new clues about the origin of cancer

  A study by Travis H. Stracker, researcher at the Institute for Research in Biomedicine (IRB Barcelona), in collaboration with scientists at the Memorial Sloan Kettering Cancer Center (MSKCC) in New York, reveals new information about the origin of tumors. In this study, published in the journal Proc more

White papers DNA Replication

• siRNA Silencing of Lamin A and Quantification of the Knockdown Effect via qPCR
  

  Lamins are structural proteins which form a thin fibrous layer called the nuclear lamina. Currently, three types of lamins are known in mammalian cells: lamin A, B, and C. Lamins may be involved in DNA replication, chromatin organization, differentiation, nuclear structural support, nuclear envelope reassembly, and several other processes. Mutations of lamin A can cause muscular dystrophy, dilated cardiomyopathy, familiar partial lipodystrophy [3], and other disorders. For the detailed analysis of the different functions of this more than 70 kDa large protein, the expression should be blocked. more

Publications DNA Replication

• Increased genome instability in human DNA segments with self-chains: homology-induced structural variations via replicative mechanisms

  Environmental factors including ionizing radiation and chemical agents have been known to be able to induce DNA rearrangements and cause genomic structural variations (SVs); however, the roles of intrinsic characteristics of the human genome, such as regional genome architecture, in SV formation an more

• Fragile DNA Motifs Trigger Mutagenesis at Distant Chromosomal Loci in Saccharomyces cerevisiae

  by Natalie Saini, Yu Zhang, Yuri Nishida, Ziwei Sheng, Shilpa Choudhury, Piotr Mieczkowski, Kirill S. Lobachev DNA sequences capable of adopting non-canonical secondary structures have been associated with gross-chromosomal rearrangements in humans and model organisms. Previously, we have shown t more

• Methylation of Histone H3 on Lysine 79 Associates with a Group of Replication Origins and Helps Limit DNA Replication Once per Cell Cycle

  by Haiqing Fu, Alika K. Maunakea, Melvenia M. Martin, Liang Huang, Ya Zhang, Michael Ryan, RyangGuk Kim, Chii Meil Lin, Keji Zhao, Mirit I. Aladjem Mammalian DNA replication starts at distinct chromosomal sites in a tissue-specific pattern coordinated with transcription, but previous studies have more

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