Compound Libraries

News Compound Libraries

• Lead Discovery Center participates in new pan-European drug discovery platform

  The European Lead Factory, a novel platform for innovative drug discovery, was launched early February by an international consortium of 30 partners including the Lead Discovery Center GmbH (LDC). LDC is an expert in the discovery and generation of small molecule lead series by translating basic res more

• Plasticell signs collaboration with UCB

  Plasticel has announced signing of a collaboration agreement with UCB. Under the terms of the agreement, UCB will supply Plasticell with drug compound libraries with known biological targets. Plasticell will screen these using its award-winning CombiCult™ technology to discover new cell signaling pa more

• Novel Inhibitors of MurA, an Antibacterial Target Enzyme

  The occurrence of infectious diseases has been increased dramatically during the past 20 years, due to antibiotic resistance, global warming and globalization (intense travelling). Primarily, the resistance of bacteria against existing antibiotics, caused particularly by adding antibiotics in animal more

Publications Compound Libraries

• Target deconvolution techniques in modern phenotypic profiling

  February 2013 Publication year: 2013Source:Current Opinion in Chemical Biology, Volume 17, Issue 1 The past decade has seen rapid growth in the use of diverse compound libraries in classical phenotypic screens to identify modulators of a given process. The subsequent process of identify more

• Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors

  Available online 26 February 2013 Publication year: 2013Source:European Journal of Pharmaceutical Sciences Poly(ADP-ribose) polymerases (PARPs) or diphtheria toxin like ADP-ribosyl transferases (ARTDs) are enzymes that catalyze the covalent modification of proteins by attachment of ADP- more

• Optimization of molecular docking scores with support vector rank regression

  Abstract This work introduces the support vector rank regression (SVRR) algorithm for the optimization of molecular docking scores. Seven original docking scores reported by two docking software were integrated by the SVRR algorithm. The resulting SVRR scores showed an average of 12.1% improveme more

Market studies Compound Libraries

• Biosignal Limited (BOSDA) - Financial and Strategic SWOT Analysis Review

  Biosignal Limited (Biosignal) is a publicly held Australia-based biotechnology company. The company primarily focused on research and development activities. The company started research on unique anti-biofilm technology that is developed at the University of New South Wales (UNSW). Later, with a te more

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