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TiGenix announced that upon review of the safety data of the first three patients of the third cohort of the company's Phase IIa clinical trial in rheumatoid arthritis (Cx611) it has received the go-ahead from the independent Safety Monitoring Board to recruit and dose the remaining patients of this more
MediGene AG continues clinical development of its drug candidate RhuDex® by initiating a clinical formulation study. The trial objective is to develop an optimized oral formulation of the active substance suitable for the treatment of chronic diseases. The results of this formulation study are expec more
The results of a Phase I clinical trial of gene therapy for limb-girdle muscular dystrophy type 2C (a rare neuromuscular disease) have just been published in the journal Brain. The trial started in December 2006 and has been sponsored by Généthon (the not-for-profit research lab created by the Frenc more
Biomarkers are currently changing the way we diagnose and treat diseases. Today pharmacodynamic biomarkers are widely used in the industry elaborating optimal dosing of new drugs and predictive biomarkers have an enormous potential for companion diagnostics more
The Nobel Assembly awarded this year's Nobel Prize in Medicine to Elizabeth H. Blackburn, Jack W. Szostak, and Carol W. Greider for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. With their ingenious genetic research and meticulous biochemical studies, they not only solved a fundamental problem in biology but also opened a new field of research and initiated the development of potential therapies against disease more
Innovative drugs are the lifeblood of pharmaceutical companies, but the cost of developing them is rising to unsustainable levels. Pharma executives are already saying that as the economy falters, they foresee bleak prospects and mergers unless their companies get more innovative drugs into their pipelines. The clock is ticking on the race to increase productivity, as key patents worth a projected $30 billion in revenue will expire between 2010 and 2013, opening the floodgates to competition from generics, according to Barbara Ryan, an analyst at Deutsche Bank. This imperative is propelling increased outsourcing of R&D operations as companies trim overcapacity. more
Abstract In HIV infections, homoeostasis of T cells is dysregulated such that there is a depletion of CD4+ T cells and a progressive loss of naïve CD4+ and CD8+ T cells. Methodologies that can improve the function of some or all of these cells will likely enhance immune responsiveness in HIV infe more
Abstract A single‐center, open‐label, and dose‐escalation clinical trial has been performed using a novel electrochemical transdermal patch comprising a drug‐loaded hydrogel sandwiched between two silver electrodes. The lower electrode is attached flatly to skin via an adhesive layer. This nonion more
Abstract Aminoglycosides and other compounds can promote premature termination codon (PTC) readthrough constituting a potential therapy for patients with nonsense mutations. In a cohort of 190 propionic acidemia (PA) patients, we have identified 12 different nonsense mutations, six of them novel, more
Introduction GlobalData's clinical trial report, “Psoriasis Global Clinical Trials Review, H1, 2012" provides data on the Psoriasis clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Psoriasis. It includes an overview of the trial number more
Introduction GlobalData's clinical trial report, “Male Hypogonadism Global Clinical Trials Review, H1, 2012" provides data on the Male Hypogonadism clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Male Hypogonadism. It includes an overv more
Introduction GlobalData's clinical trial report, “Anal Fissure Global Clinical Trials Review, H1, 2012" provides data on the Anal Fissure clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Anal Fissure. It includes an overview of the tri more
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AIDS Clinical Trials Group The AIDS Clinical Trials Group (ACTG) is the largest HIV clinical trials organization in the world, playing a major role in setting standards of care for HIV infection and opportunistic diseases related to HIV and AID ... more
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