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Nobel Prize for Solving the End-Replication Problem
The Nobel Assembly awarded this year's Nobel Prize in Medicine to Elizabeth H. Blackburn, Jack W. Szostak, and Carol W. Greider for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. With their ingenious genetic research and meticulous biochemical studies, they not only solved a fundamental problem in biology but also opened a new field of research and initiated the development of potential therapies against disease...
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HelpCorner - xCELLigence System
<p><strong>General</strong><br /> <br /> <strong>FAQ</strong>: How can I save time when using the xCELLigence System?<br /> <br /> <strong>HelpCorner</strong>: Automated monitoring and data collection contribute to significant time savings when using the xCELLigence System, with only a few...
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High-Throughput Cardiac Gene Expression Analysis Using the Universal ProbeLibrary and the Novel LightCycler® 1536 Real-Time PCR System
Although congenital heart malformations are the most common birth defects in humans, the underlying pathomechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defects (e.g., CITED2, GATA4, NKX2-5) have been identified. However, most heart malformations display variable expressivity and penetrance, which indicates a multifactorial and multigenic basis. This suggests that the regulatory context of transcription factors plays an important role in the manifestation of the defects. In order to better understand the molecular pathways in cardiogenesis and disease we studied the global genetic network that is deregulated in malformed hearts...
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MagNA Pure 96 Cellular RNA Kits: RNA Isolation on the Fast Lane
Advancements in high-throughput gene expression analysis have set a new demand for automated isolation of cellular RNA from high sample numbers in parallel. The availability of the innovative MagNA Pure 96 System together with dedicated kits, protocols, and consumables sets a new standard in truly walkaway high-throughput automated nucleic acid sample preparation...
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The New MagNA Pure 96 DNA and Viral NA Kits: Maximal Speed Combined with High Recovery
The MagNA Pure 96 System is a brand-new system recently introduced to the market: it is a fully automated, ultra-fast system for high-throughput isolation of high- quality nucleic acids from various sample types that can handle sample volumes of up to 1 ml. The main features of the new system were described in the preceding Biochemica issue (4/2009). This system uses optimized kits with prefilled, ready-to-use reagents in combination with the appropriate automated isolation protocols. The configuration of the kits is based on the well-established magnetic bead technology that has been used successfully on different MagNA Pure Systems for many years now. The MagNA Pure 96 Kits are composed of reagent trays with different prefilled, sealed containers for the buffers and special bottles containing the magnetic particles. All kits are available as small-volume (SV) and large-volume (LV) variants, depending on the sample amount to be processed. This article describes the features and the performance of the two M...
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