X-ray crystallography - 101 News

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X-ray crystallography - 101 News

Tip: You can further refine your news selection by departments, organizations, countries and industries.

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New vulnerability discovered in hospital bacterium

Team of researchers identifies promising target for drug development

24-Jun-2025 - It is one of the most resistant pathogens in medicine: Pseudomonas aeruginosa defies many antibiotics, forms protective biofilms and survives even under conditions of severe stress. Now, an international team of researchers at the Centre for Structural Systems Biology (CSSB) on the DESY campus ...

X-ray crystallography antibiotic resistance bacterial biofilms
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Concept Life Sciences and Accelero Biostructures partner to advance X-ray crystallography in early drug discovery

Up to 10 times faster drug development expected

11-Dec-2024 - UK-based Concept Life Sciences (Concept) and Accelero Biostructures (Accelero) in the US have formed an industry-leading partnership which will help pharma businesses worldwide speed up drug development by up to tenfold. The collaboration accelerates the timeline for progressing from drug ...

X-ray crystallography drug discovery proteins
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Key to Improving Cancer Treatments Discovered

Discovery Paves the Way for the Development of Precise Inhibitors

07-Jun-2024 - Some cancer drugs cause severe side effects because they are not working accurately enough. A team at the University of Würzburg led by biochemist Caroline Kisker has now discovered why. The small protein ubiquitin is involved in almost every cellular process in our body: it orchestrates the ...

X-ray crystallography cancer cancer drugs
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A Second Chance for New Antibiotic Agent

Drug candidate rejected 20 years ago may now be more selective thanks to new research

22-May-2024 - Twenty years ago, a drug candidate was rejected due to its side effects. Researchers have now figured out how to potentially make a successor molecule more selective. An increasing number of bacteria have become resistant to many commonly used antibiotics. Researchers from Bochum have discovered ...

X-ray crystallography active ingredient candidates antibiotic resistance
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Imaging the smallest atoms provides insights into an enzyme's unusual biochemistry

This could help in the design of enzymes for the chemical industry

29-Sep-2023 - When your wounds heal and your liver detoxifies a poison such as histamine you ingested, you can thank the class of enzymes known as copper amine oxidases for their assistance. Identifying the exact positions of the smallest hydrogen atoms in these enzymes is challenging with commonly used ...

X-ray crystallography artificial enzymes biochemistry
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The protective armor of superbug C.difficile revealed

Spectacular structure of chain-mail may explain the success of C.diff at defending itself against antibiotics and immune system molecules

01-Mar-2022 - The spectacular structure of the protective armour of superbug C.difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail. This assembly prevents molecules getting in and provides a new target for future treatments, according to the ...

X-ray crystallography antibiotic resistance antibiotics
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How ethane-consuming archaea pick up their favorite dish

Scientists sucessfully decoded the structure of the enzyme responsible for ethane fixation

09-Jul-2021 - Hot vents in the deep sea are home to microbes that feed on ethane. They were discovered recently from scientists of the Max Planck Institute for Marine Microbiology. Now the researchers from Bremen succeeded in finding an important component in the microbial conversion of the gas. They were able ...

X-ray crystallography archaea enzymes
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Cellular powerplant recycles waste gases

The idea is to use the power of bacteria to turn toxic waste gases into valuable compounds such as acetate or ethanol

19-Nov-2020 - Carbon monoxide is a very poisonous gas. Humans die within minutes when they inhale it. However, some microorganisms tolerate carbon monoxide and even use it to breathe and replicate. Knowledge about how these bacteria survive opens a window into the primeval times of the earth and the origin of ...

X-ray crystallography acetate bacteria
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Getting to the heart of an enzyme

Decoding the heart of NatC: X-rays help shed light on structure

10-Nov-2020 - A team led by Oliver Daumke at the MDC has determined the three-dimensional structure of the NatC acetyltransferase in an article published in Nature Communications. This enzyme modifies cell proteins to enable them to perform their functions correctly. In cancer cells, however, NatC is often ...

X-ray crystallography Acetylation acetyltransferases
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How deadly parasites ‘glide’ into human cells


X-ray analysis reveals structure of molecular machinery of malaria and toxoplasmosis pathogens

03-Nov-2020 - An investigation at DESY's X-ray source PETRA III provides new insights into the molecular machinery by which certain parasites travel through the human organism. The study, led by Christian Löw from the Hamburg branch of the European Molecular Biology Laboratory EMBL, analyzed the so-called ...

X-ray crystallography malaria nuclear magnetic resonance spectroscopy
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