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It is not always the hardware! Method development using different HPLC column selectivities

In LC-MS ion suppression could be a major issue causing unreliable results. Learn about what causes ion suppression and how to move the analyte out of this front. Get an overview of certain selectivity´s and how to choose them. Learn how to transfer a method from spherical silica to core shell materials. Hear solutions to injection related issues, what else has influence on the results and general tips and tricks to avoid commonly seen issues.

Topics: vials, venlafaxine, neuroleptics, method development, HPLC, fentanyl, buprenorphine, antidepressants, LC-MS, column selectivities, ion suppression, C18, phenyl columns, solid core, norfentanyl, SPE, Orbitrap LC-MS, glass quality, amisulpride, doxepine, pregabalin, gabapentin