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Toxicity

News Toxicity

  • The tightest non-aminoglycoside ligand for the bacterial ribosomal RNA A-site

    A research group at Tohoku University has made a significant discovery with positive implications for the development of bacteria-fighting drugs. The aminoacyl-tRNA site (A-site) of the 16S RNA decoding region in the bacterial ribosome looks promising for a new era of antibiotic drug development. Tr more

  • Liver-on-a-chip, the ideal test environment for CRISPR

    Two Arizona State University professors are among the first recipients ofSomatic Cell Genome Editing (SCGE) grants from the National Institutes of Health Common Fund. The $2,600,000, five-year grant will fund the first study of the genome editing technology CRISPR to be used on a "human liver on-a-c more

  • Titanium dioxide from sunscreen is polluting beaches

    Scientists have found that sunscreen from bathers releases significant quantities of polluting TiO2 (titanium dioxide) into the sea. This has the potential to harm marine life. This work, which comes from research on beaches in the South of France, was presented at the Goldschmidt geochemistry confe more

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Videos Toxicity

Nano-enabled chemotheraphy for pancreatic cancer with improved safety and efficacy

Authors Huan Meng and Xiangsheng Liu describe the custom-designing of a mesoporous silica nanoparticle (MSNP) platform to reduce the toxicity of irinotecan, a drug included in the four-drug regimen FOLFIRINOX, to treat pancreatic ductal adenocarcinoma (PDAC). more

Bacteria Found to Produce Compounds Toxic to Humans

A Scripps Oceanography-led research team discovered for the first time that a common marine sponge hosts bacteria that specialize in the production of toxic compounds nearly identical to man-made fire retardants. more

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Infographics Toxicity

Natural vs. Man-Made Chemicals

The term ‘chemophobia’ has been used on social media amongst chemists with increasing regularity over the past year. Defined as ‘a fear of chemicals’, more specifically it refers to the growing tendency for the public to be suspicious and critical of the presence of any man-made (synthetic) chemical more

Lethal Doses of Water, Caffeine and Alcohol

Today’s graphic is a whimsical look at lethal doses of chemicals we consume on a regular basis. Whilst it may be more common to view chemicals in a black and white framing of ‘toxic’ or ‘non-toxic’, the reality is more of a sliding scale of toxicity. The admission of too much of any chemical into th more

The Chemistry of Poisons

This graphic is the first in a planned series looking at the effects and chemistry of a range of different poisons. As such, it seemed appropriate to start with one of the most well known poisons: arsenic. Arsenic has been used by poisoners for centuries, primarily in the form of white arsenic, or a more

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Events Toxicity

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The Use of Microsampling to Improve the Relevance of Toxicity Study Data

Microsampling provides the ability to relate toxicity directly to exposure in a single animal and obtain a full TK profile from that animal, allowing for a more accurate understanding of the toxicokinetics and the effect of exposure.

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Dealing with Reactive Drug Metabolites in Drug Discovery: Can We Predict Toxicities of Drug Candidates that form Reactive Metabolites?

A perceived notion of reactive metabolite formation as a standalone predictor of toxicity risks may be over exaggerated and that other factors such as body burden of the reactive moiety may be a better predictor. Join Deepak Dalvie of Pfizer as he discusses pragmatic risk mitigation strategies and t

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On-Demand

Designing Better Drug Candidates

Only about 4% of candidate drugs reach the market. The main culprits of this failure are due to issues with dosing , exposure and toxicity. Join us as Dr. Paul Leeson shares how improving candidate quality can be facilitated by the selection of lead-like chemical starting points, control of physicoc

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Definition

Toxicity

Toxicity Toxicity is the degree to which something is able to produce illness or damage to an exposed organism. Toxicity can refer to the effect on a whole organism , such as a human or a bacterium or a plant, or to a substructure, such as ... more

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