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It is well known that natural products are valuable resources for drug discovery and development. In particular, plant-derived natural products have greatly contributed to the area of cancer chemotherapeutics. Many antitumor drugs currently in clinical use, such as paclitaxel, vinca alkaloids ...
A new, biocompatible photooxygenation catalyst that can selectively oxygenate and degrade the pathogenic aggregation of Alzheimer's disease (AD)-related amyloid-β peptide (Aβ) under near-infrared (NIR) light irradiation is developed. The catalyst was able to oxygenate Aβ embedded under the skin ...
Novel materials enable controlled and sustained release of chlorhexidine
Pertinax Pharma today announces the commercial launch of its unique, proprietary Pertinax® technology, which provides controlled and sustained delivery of chlorhexidine (CHX). The revolutionary new technology has a wide range of potential applications across the wound care, dentistry, medical ...
When environmental and soil chemist Baoshan Xing at the University of Massachusetts Amherst began reading in 2014 that a new, two-dimensional material known as layered black phosphorous (BP) was gaining the attention of biomedical researchers for use in drug delivery systems and tumor ...
Chemists at the University of Alabama at Birmingham have designed triple-threat cancer-fighting polymer capsules that bring the promise of guided drug delivery closer to preclinical testing. These multilayer capsules show three traits that have been difficult to achieve in a single entity. They ...
A subtle change affects its aggregation behavior and stabilizes a form with enhanced toxicity
Much of the research on Alzheimer's disease has focused on the amyloid beta protein, which clumps together into sticky fibrils that form deposits in the brains of people with the disease. In recent years, attention has turned away from the fibrils themselves to an intermediate stage in the ...
Nature paper demonstrates that toxicity in AD is induced by pyroglutamate Abeta and is tau protein dependent
Probiodrug AG announced its scientists and academics collaborators published seminal findings on the role of pyroglu Aβ in AD pathology in Nature. The new findings add to the growing body of evidence that pyroglu Aβ plays a crucial role in the initiation of AD. In addition, the research results ...
Roche’s xCELLigence System used to investigate effects of lunar and Martian dust on mammalian skin
Exposure to lunar dust during the Apollo missions resulted in reports of ocular, respiratory and dermal irritation, suggesting that lunar dust is a potential risk to human health. Because it is highly reactive and fine, extraterrestrial dust can quickly become wide-spread in human habitats. To ...
Broad Claims Granted for Cytotoxicity Profiling and Chemical Compound Testing
ACEA Biosciences, Inc. reported the issuance of a new U. S. Patent for chemical compound screening, with important applications in the development of new pharmaceutical products. Testing and profiling of these candidate compounds by means of ACEA's real-time, label-free microelectronic technology ...
Developing more sensitive methods of biomedical imaging that are effective with minimal amounts of contrast agents is an important challenge in the early and accurate diagnosis of illnesses. A new class of materials that appear promising in this quest were introduced in 2006 by Prof. Wenbin Lin ...