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452 Current news about the topic chemotherapy

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New biomarker for personalized treatments against cancer

18-Apr-2019

Cancer cells are characterised by the ability to evade apoptosis, a type of programmed cell death that allows the organism to remove damaged cells. Many studies devoted to new chemotherapy treatments aim to induce apoptosis and thus remove cancer cells or reduce the size of the tumour. Scientists ...

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Mapping oesophageal cancer genes leads to new drug targets

06-Feb-2019

Mutations that cause oesophageal adenocarcinoma (OAC) have been mapped in unprecedented detail - unveiling that more than half could be targeted by drugs currently in trials for other cancer types. This research could help stratify oesophageal cancer patients to give them more personalised ...

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Revealing the path of a metallodrug in a breast cancer cell

05-Feb-2019

Some types of cancer cannot be treated with classical chemotherapy. Scientists from Inserm, CNRS, Sorbonne University, PSL university, University Grenoble Alpes and ESRF, the European Synchrotron, are working on a metallorganic molecule as an antitumor drug. Their research has given thorough ...

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How Drugs Can Minimize the Side Effects of Chemotherapy

11-Jan-2019

Researchers at the University of Zurich have determined the three-dimensional structure of the receptor that causes nausea and vomiting as a result of cancer chemotherapy. The study explains for the first time why some drugs work particularly well in ameliorating these side effects. The results ...

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An errant editing enzyme promotes tumor suppressor loss and leukemia propagation

08-Jan-2019

Researchers at University of California San Diego School of Medicine report that detection of "copy editing" by a stem cell enzyme called ADAR1, which is active in more than 20 tumor types, may provide a kind of molecular radar for early detection of malignancies and represent a new therapeutic ...

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Tumors backfire on chemotherapy

03-Jan-2019

Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery. This approach, called 'neoadjuvant' therapy, helps to reduce the size of the tumor to facilitate breast-conserving surgery, and can even eradicate the tumor, leaving few or no cancerous cells for the ...

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Global trial shows CAR T therapy can lead to durable remissions in non-Hodgkin's lymphoma

04-Dec-2018

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah® (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL). ...

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Cancer identity technology makes it easier to find a tumor's 'address'

20-Nov-2018

Purdue University researchers have developed a technology aimed at making it easier to deliver cancer treatment to the right "address" in the body while also easing the painful side effects of chemotherapy on patients. One of the big issues with chemotherapy is that most treatment approaches ...

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Neutralizing reactive nitrogen molecules to enhance cancer immunotherapy

31-Oct-2018

Immunotherapy -- harnessing T-cells to attack cancer cells in the body -- has given hope to patients who endure round after round of treatment, including chemotherapy, to little effect. For all of its promise, however, immunotherapy still benefits only a minority of patients -- a reality driving ...

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Focussed ultrasound used to improve effects of cancer drugs

12-Jul-2018

Researchers have made a breakthrough in more precisely targeting drugs to cancers. Using ultrasound and lipid drug carriers (liposomes), a multi-disciplinary team of biomedical engineers, oncologists, radiologists and anaesthetists at the University of Oxford have developed a new way to improve ...

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