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455 Current news about the topic chemotherapy

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Cellular stress causes cancer cell chemoresistance

Postgenomic technologies reveal new mechanism of stress-induced chemoresistance

12-Jun-2020

Resistance of cancer cells against therapeutic agents is a major cause of treatment failure, especially in recurrent diseases. An international team around the biochemists Robert Ahrends from the University of Vienna and Jan Medenbach from the University of Regensburg identified a novel mechanism ...

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Taking Aim at Gastric Cancer

New approach to selective chemotherapy

27-Jan-2020

A novel drug, named “FerriIridium”, can simultaneously help diagnose and treat gastric cancer. The initially weakly active precursor (prodrug), based on an iridium-containing compound, is selectively activated only after reaching the interior of a tumor cell. This is possible because of the ...

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French biotech start-up raises €800k in seed funding

22-Jan-2020

Seekyo, a privately-owned biotech start-up specializing in the development of the next generation of chemotherapies,announces that it has completed a seed round of fundraising to the value of €800k ($889K). Thefunds will allow the company to accelerate the development of its flagship drug ...

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New biomarker for personalized treatments against cancer

18-Apr-2019

Cancer cells are characterised by the ability to evade apoptosis, a type of programmed cell death that allows the organism to remove damaged cells. Many studies devoted to new chemotherapy treatments aim to induce apoptosis and thus remove cancer cells or reduce the size of the tumour. Scientists ...

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Mapping oesophageal cancer genes leads to new drug targets

06-Feb-2019

Mutations that cause oesophageal adenocarcinoma (OAC) have been mapped in unprecedented detail - unveiling that more than half could be targeted by drugs currently in trials for other cancer types. This research could help stratify oesophageal cancer patients to give them more personalised ...

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Revealing the path of a metallodrug in a breast cancer cell

05-Feb-2019

Some types of cancer cannot be treated with classical chemotherapy. Scientists from Inserm, CNRS, Sorbonne University, PSL university, University Grenoble Alpes and ESRF, the European Synchrotron, are working on a metallorganic molecule as an antitumor drug. Their research has given thorough ...

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How Drugs Can Minimize the Side Effects of Chemotherapy

11-Jan-2019

Researchers at the University of Zurich have determined the three-dimensional structure of the receptor that causes nausea and vomiting as a result of cancer chemotherapy. The study explains for the first time why some drugs work particularly well in ameliorating these side effects. The results ...

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An errant editing enzyme promotes tumor suppressor loss and leukemia propagation

08-Jan-2019

Researchers at University of California San Diego School of Medicine report that detection of "copy editing" by a stem cell enzyme called ADAR1, which is active in more than 20 tumor types, may provide a kind of molecular radar for early detection of malignancies and represent a new therapeutic ...

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Tumors backfire on chemotherapy

03-Jan-2019

Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery. This approach, called 'neoadjuvant' therapy, helps to reduce the size of the tumor to facilitate breast-conserving surgery, and can even eradicate the tumor, leaving few or no cancerous cells for the ...

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Global trial shows CAR T therapy can lead to durable remissions in non-Hodgkin's lymphoma

04-Dec-2018

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah® (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL). ...

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