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166 Current news about the topic bone marrow

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Epigenetics key to daily production of 10 billion blood cells without mistakes

Study reveals a gene key for blood cell specialisation

10-Aug-2020

Just one in 2,000 bone marrow cells are hematopoietic stem cells (HSC), but these are the source of the ten billion blood cells humans make every day. In a new study published, researchers from the Centre for Genomic Regulation (CRG), in Barcelona, show that the epigenetic regulator Phf19 is ...

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Innovative method delivers new insights into the stem cell microenvironment – Bone marrow in 3D

02-Jan-2020

Researchers from the European Molecular Biology Laboratory (EMBL) and the German Cancer Research Center (DKFZ) in Heidelberg, Germany, have developed new methods to reveal the three-dimensional organisation of bone marrow at a single cell level. Since bone marrow harbours blood stem cells ...

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State of 'hibernation' keeps haematopoietic stem cells young

Niches in the bone marrow protect from ageing

09-Dec-2019

All tissues age. The blood-forming system is especially affected by ageing processes. Haematopoietic stem cells, the precursors to blood and immune cells, age exceptionally fast, losing the ability to divide and regenerate. This weakens the immune system and increases the risk of blood cancer. An ...

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Megakaryocytes act as „bouncers“ restraining cell migration in the bone marrow

17-Jul-2019

Scientists at the University Würzburg and University Hospital of Würzburg found that megakaryocytes act as “bouncers” and thus modulate bone marrow niche properties and cell migration dynamics. Hematopoiesis is the process of forming blood cells, which occurs predominantly in the bone marrow. The ...

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Stem Cells Regulate Their Fate by Altering Their Stiffness

Doing More with Less

16-Jan-2019

In adults, mesenchymal stems cells (MSCs) are primarily found in bone marrow and they play a vital role in repair of damaged organs. The transformation of a single MSC into complex tissue like cartilage and bone starts with its association with other MSCs in order to form microscopic clusters via ...

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Closing in on mystery surrounding dangerous blood syndromes

Genetically driven MDS enabled by gene linked to metabolism and oxygen in cells

24-Aug-2018

Scientists may be on the road to solving the mystery of a group of mostly incurable blood diseases called myelodysplastic syndromes (MDS), which cause people to have immature, malfunctioning bone marrow cells that fuel a diverse set of health problems and can lead to leukemia. MDS is linked to a ...

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Artificial gene defect reveals target to fight genetic disease

13-Jun-2018

DNA Repair is essential for a healthy organism. In every day of our lives, tens of thousands of damages occur in the genetic material of our cells. Hence, it is not surprising that a broad variety of repair mechanisms developed in the course of evolution that enables cells to quickly react and ...

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Researchers engineer human bone marrow tissue

06-Jun-2018

Every day in the bone marrow several billion blood cells are formed. This constant supply is ensured by blood stem cells located in special niches within the marrow. These stem cells can multiply and mature into red and white blood cells, which then leave the bone marrow and enter the ...

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Discovery of novel Malaria parasite behaviour offers new target for treatment

28-May-2018

Researchers have demonstrated novel parasite behaviour which offers a potential new target for malaria diagnosis and intervention. Malaria, a blood borne disease caused by single cell parasites, remains a major global public health issue with millions of cases, and nearly half a million deaths ...

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Researchers succeed in cultivating cartilage from stem cells

19-Apr-2018

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific ...

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