Sex-specific processes in schizophrenia and bipolar disorder

13-Nov-2019

Recent studies have found a high genetic similarity of the psychiatric diseases schizophrenia and bipolar disorder, whose disease-specific changes in brain cells show an overlap of more than 70 percent. These changes affect gene expression, i.e., transcription of genes for the purpose of ...

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28-Aug-2018

A global study conducted by the international "Brainstorm Consortium" has, for the first time, analysed the genome of 1.1 million patients with psychiatric and neurological disorders and has shown that certain brain disorders are genetically related. For example, there is a significant ...

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20-Aug-2018

Circadian rhythms are regular 24-hour variations in behaviour and activity that control many aspects of our lives, from hormone levels to sleeping and eating habits. In the largest ever genetic study of circadian rest-activity cycles in humans, scientists at the University of Glasgow have ...

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13-Feb-2018

Even if you haven't ridden your bike in years, you probably remember how to do so without giving it much thought. If you're a skilled piano player, odds are you can easily sit down and play a song you've rehearsed before. And, when you drive to work, you're likely not actively thinking about your ...

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10-May-2017

An international collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) , with major participation from Yokohama School of Medicine, Harvard Medical School, and UC San Diego, has identified the molecular mechanism behind lithium's effectiveness in ...

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30-Sep-2016

Loneliness is linked to poor physical and mental health, and is an even more accurate predictor of early death than obesity. To better understand who is at risk, researchers at University of California San Diego School of Medicine conducted the first genome-wide association study for loneliness — ...

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01-Aug-2016

New measurements may have lifted the veil on the vexingly elusive interactions through which lithium can moderate the manic highs and debilitating lows experienced by people who suffer from bipolar disorder--about 2.6 percent of Americans, according to the National Institute of Mental ...

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24-Mar-2016

In recent years, a common parasitic infection - as many as a third of the world's population may have it - has been linked to a range of psychiatric disorders, including schizophrenia and bipolar disorder, as well as behavioral dysregulation such as suicide attempts and car accidents. Now a new ...

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13-Oct-2015

A multicenter study of young patients with bipolar disorder provides what may be the most scientifically rigorous demonstration to date that lithium can also be safe and effective for children suffering from it. The study, led by a researcher at the Johns Hopkins Children's Center affirms what ...

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Resting neurons actively regulate gene expression through calcium signaling

16-Jun-2014

Researchers from Tufts have gained new insight into a protein associated with bipolar disorder. The study, published in Science Signaling, reveals that calcium channels in resting neurons activate the breakdown of Sp4, which belongs to a class of proteins called transcription factors that ...

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