RNA - 4 News by Uni Frankfurt am Main
Structural biology: Molecular scissors caught in the act
Structure of an enzyme crucial for tRNA maturation sheds light on cause of neurodegenerative disorders
17-Jul-2023 - In all living organisms, the biomolecule transfer RNA (tRNA) plays a fundamental role in protein production. tRNAs are generated from precursor molecules in several steps. The enzyme tRNA splicing endonuclease (TSEN), among other things, catalyzes one step in this process. Mutations in TSEN lead ...
The Paul Ehrlich and Ludwig Darmstaedter Prize 2022 will be awarded to Katalin Karikó, Özlem Türeci and Uğur Şahin
The three award winners are being honoured for their achievements in the development of mRNA for preventive and therapeutic purposes
21-Sep-2021 - Katalin Karikó, Özlem Türeci, and Uğur Şahin have established a technology platform that is likely to initiate a paradigm shift in some areas of medicine - away from the external application of immunising antigens or therapeutically effective proteins to their internal production within the cells ...
Small RNAs link immune system and brain cells
Sex-specific processes in schizophrenia and bipolar disorder
13-Nov-2019 - Recent studies have found a high genetic similarity of the psychiatric diseases schizophrenia and bipolar disorder, whose disease-specific changes in brain cells show an overlap of more than 70 percent. These changes affect gene expression, i.e., transcription of genes for the purpose of ...
RNA: a vicious pathway to cancer?
16-Aug-2017 - According to the current doctrine, cancer cells develop due to mutations in genomic DNA. But could it be also caused also by faulty RNA molecules? A number of clues are pointing to this surprising hypothesis. Rolf Marschalek from the Institute of Pharmaceutical Biology at Goethe University ...
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