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News Myelofibrosis

  • Hematoxylin as a killer of CALR mutant cancer cells

    Patients with myeloproliferative neoplasm (MPN), a group of malignant diseases of the bone marrow, often have a carcinogenic mutated form of the calreticulin gene (CALR). Scientists of the research group of Robert Kralovics, Adjunct Principal Investigator at the CeMM Research Center for Molecular Me more

  • Genetic model identifies primary myelofibrosis outcomes

    A group of investigators from Mayo Clinic and multiple academic research centers in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell transplant to treat their disease. The group's findings we more

  • 'Chromosomal Chaos:' Complex array of mutations found in rare, aggressive leukemia

    Sezary syndrome (SS), an aggressive leukemia of mature T cells, is more complicated at a molecular level than ever suspected, according to investigators from the Perelman School of Medicine at the University of Pennsylvania. With a poor prognosis and limited options for targeted therapies, fighting more

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Myelofibrosis Myelofibrosis with myeloid metaplasia, also known as agnogenic myeloid metaplasia, chronic idiopathic myelofibrosis, and primary myelofibrosis, was first described in 1879 and is currently classified as a myeloproliferative disease ... more


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