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News Mutations

  • Gene therapy for mitochondrial diseases

    Mitochondrial disease is now thought to be the second most commonly diagnosed genetic disease worldwide, and, unfortunately, there are still no proven treatment strategies for those diagnosed. Scientists from the Max Planck Institute for Biology of Ageing in Cologne were involved in collaborations t more

  • Genome Duplication Drives Evolution of Species

    Polyploid plants have a duplicate set of chromosomes. As a result, large-scale genetic changes are therefore possible in the new species, making it more adaptable in comparison with the parental species, as has now been proven by UZH researchers with rockcress. Many wild and cultivated plants arise more

  • How infectious bacteria hibernate through treatment

    Disease-causing bacteria can develop resistance to antibiotics – which are then no longer effective in treating the infection. Yet they also have another tactic to avoid being killed off by antibiotic treatment. Some cells of the population quietly hide in a dormant state and wait for the danger to more

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New Strategy to Identify Small Molecule Therapies: Usher Syndrome III Case Study

Characterized by progressive deafness, blindness and variable balance disorder, Usher syndrome type III (USH3) is caused by destabilizing mutations in the gene encoding the clarin-1 protein (CLRN1).


Designing a Novel Cancer Drug: From Hit ID to Candidate

Many cancers exhibit dysregulation of the MAPK/ERK (MEK) signalling pathway driven by mutations in multiple enzymes within the pathway. Listen to our scientists describe a project to identify a novel, potent, selective small-molecule inhibitor targeting a specific kinase in this pathway.

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Mutation In biology , mutations are changes to the base pair sequence of the genetic material of an organism. Mutations can be caused by copying errors in the genetic material during cell division , by exposure to ultraviolet or ionizing ra ... more


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