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Frontotemporal Dementia

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Publications Frontotemporal Dementia

  • CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity

    Hexanucleotide-repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). The nucleotide-repeat expansions are translated into dipeptide-repeat (DPR) proteins, which are aggregation prone and may contribute to neurodegene more

  • Genetics of dementia in a Finnish cohort

    Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are the two most common neurodegenerative dementias. Variants in APP, PSEN1 and PSEN2 are typically linked to early-onset AD, and several genetic risk loci are associated with late-onset AD. Inherited FTD can be caused by hexanucleotide expa more

  • Nuclear pores: the gate to neurodegeneration

    Nuclear pores: the gate to neurodegeneration Nuclear pores: the gate to neurodegeneration, Published online: 25 January 2018; doi:10.1038/s41593-017-0066-0 Compromised compartmentalization of nucleus and cytoplasm has emerged as a central feature of aging and neurodegenerative diseases. Nucleocyto more

All publications on frontotemporal dementia

Frontotemporal dementia

Frontotemporal dementia Frontotemporal dementia (FTD) is a clinical syndrome caused by degeneration of the frontal lobe of the brain and may extend back to the temporal lobe . It is one of three syndromes caused by frontotemporal lobar degen ... more


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