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Z curve

The Z curve (or Z-curve) method is a bioinformatics algorithm for genome analysis. The Z-curve is a three-dimensional curve that constitutes a unique representation of a DNA sequence, i.e., for the Z-curve and the given DNA sequence each can be uniquely reconstructed from the other.[1] The resulting curve has a zigzag shape, hence the name Z-curve. The Z-curve method has been used in many different areas of genome research, such as replication origin identification,[2] ab initio gene prediction,[3] isochore identification,[4] genomic island identification[5] and comparative genomics.[6]


  1. ^ Zhang CT, Zhang R, Ou HY (2003). "The Z curve database: a graphic representation of genome sequences". Bioinformatics 19 (5): 593-99. Retrieved on 2007-01-26.
  2. ^ Zhang R, Zhang CT (2005). "Identification of replication origins in archaeal genomes based on the Z-curve method". Archaea 1 (5): 335-46. Retrieved on 2007-01-26.
  3. ^ Guo FB, Ou HY, Zhang CT (2003). "ZCURVE: a new system for recognizing protein-coding genes in bacterial and archaeal genomes". Nucleic Acids Research 31: 1780-89. Retrieved on 2007-01-26.
  4. ^ Zhang CT, Zhang R (2004). "Isochore structures in the mouse genome". Genomics 83 (3): 384-94. Retrieved on 2007-01-26.
  5. ^ Zhang R, Zhang CT (2004). "A systematic method to identify genomic islands and its applications in analyzing the genomes of Corynebacterium glutamicum and Vibrio vulnificus CMCP6 chromosome I". Bioinformatics 20 (5): 612-22. Retrieved on 2007-01-26.
  6. ^ Zhang R, Zhang CT (2003). "Identification of genomic islands in the genome of Bacillus cereus by comparative analysis with Bacillus anthracis". Physiological Genomics 16: 19-23. Retrieved on 2007-01-26.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Z_curve". A list of authors is available in Wikipedia.
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