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Ryanodine is a poisonous alkaloid found in the South American plant Ryania speciosa.
Additional recommended knowledge
The compound has extremely high affinity to the ryanodine receptor, a group of calcium channels found in skeletal and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it.
At nanomolar concentrations, ryanodine locks the receptor in a half-open state, whereas it fully closes them at micromolar concentration. The effect of the nanomolar-level binding is that ryanodine causes release of calcium from calcium stores in the sarcoplasmic reticulum leading to massive muscular contractions.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ryanodine". A list of authors is available in Wikipedia.|