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Reinke's edema

Reinke's edema
Classification & external resources
ICD-10 J38.4
ICD-9 478.6
DiseasesDB 32572

Reinke's edema, also known as polypoid degeneration, is the swelling of the vocal folds due to fluid collection (edema).

Additional recommended knowledge



Reinke's edema causes the vocal folds to bilaterally swell giving them an uneven, sac-like appearance. Individuals with Reinke's Edema typically have low-pitched, husky voices.


Common causes of Reinke's edema include smoking, gastroesophageal reflux, hormonal changes such as hypothyroidism and chronic voice abuse.


Histopathology: biopsy of the vocal cord may be used to help in diagnosis in some cases. Histology shows oedema in the stroma.


The first course of treatment is to remove the source of the irritant (e.g. smoking cessation, vocal rest, etc.). This can be effective if done soon after development of the edema. Surgery is also an option and can result in some restoration of the voice but is ineffective in complete restoration of the voice to its original state.


It is named for Friedrich Reinke.[1][2]

See also


  1. ^ synd/2653 at Who Named It
  2. ^ F. B. Reinke. Untersuchungen über das menschliche Stimmband. Fortschritte der Medizin, München, 1895, 13: 469-478.
  • Benign Vocal Lesions - Nodules, Polyps, Cysts. The Center for Voice at Northwestern University. Retrieved on July 24, 2007.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Reinke's_edema". A list of authors is available in Wikipedia.
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