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Polar surface area
The Polar Surface Area (PSA) is defined as the surface sum over all polar atoms, (usually oxygen and nitrogen), including also attached hydrogens.
Additional recommended knowledge
PSA is a commonly used medicinal chemistry metric for the optimisation of cell permeability. Molecules with a polar surface area of greater than 140 angstroms squared are usually believed to be poor at permeating cell membranes. For molecules to penetrate the blood-brain barrier, PSA should be less than 60 angstroms squared.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Polar_surface_area". A list of authors is available in Wikipedia.|