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Neurospora crassa



Neurospora crassa
Scientific classification
Kingdom: Fungi
Phylum: Ascomycota
Class: Ascomycetes
Order: Sordariales
Family: Sordariaceae
Genus: Neurospora
Species: crassa
Binomial name
Neurospora crassa
Shear & B.O. Dodge

Neurospora crassa is a type of red bread mold of the phylum Ascomycota. The genus name, meaning "nerve spore" refers to the characteristic striations on the spores that resemble axons.

Additional recommended knowledge

N. crassa is used as a model organism because it is easy to grow and has a haploid life cycle that makes genetic analysis simple since recessive traits will show up in the offspring. Its entire genome of seven chromosomes has been sequenced [1]. Neurospora was used by Edward Tatum and George Wells Beadle in their experiments for which they won the Nobel Prize in Physiology or Medicine in 1958. Beadle and Tatum exposed N. crassa to x-rays, causing mutations. They then observed failures in metabolic pathways caused by errors in specific enzymes. This led to the "one gene, one enzyme" hypothesis that states that specific genes code for specific proteins.

In the 24 April 2003 issue of Nature, the genome of N. crassa was reported as completely sequenced. The genome is about 43 megabases long and includes approximately 10,000 genes. There is a project underway to produce strains containing knockout mutants of every N. crassa gene.

In its natural environment, N. crassa lives mainly in tropical and sub-tropical regions. It can be found growing on dead plant matter after fires.


References

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  • Osherov, N & GS May (May 30, 2001), " ", FEMS Microbiol Lett 199(2):153-60. PMID 11377860
  • Froehlich, AC; B Noh & RD, Loros J & Dunlap JC Vierstra (December 2005), " ", Eukaryot Cell 4(12):2140-52. PMID 16339731
  • Horowitz, NH (April 1991), " ", Genetics, . PMID 1827628
  • Horowitz, NH; P Berg & M, Lederberg J, Susman M, Doebley J & Crow JF. Singer (January 2004), " ", Genetics 166(1):1-10, . PMID 15020400
  • Kaldi, K; BH Gonzalez & M Brunner (December 23, 2005), " ", EMBO Rep. PMID 16374510
  • Pittalwala, Iqbal (April 29, 2003), " ", Newsroom (University of California, Riverside), .
  • Ruoff, P (December 6, 2005), " ", Proc Natl Acad Sci USA. PMID 16314576
  1. ^ Trans-NIH Neurospora Initiative
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Neurospora_crassa". A list of authors is available in Wikipedia.
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