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## Models of nucleotide substitution
## Additional recommended knowledge
## Jukes and Cantor's one-parameter model
*P*_{xx(1)}= 1 − 3μ
*P*_{xx(t + 1)}= (1 − 3μ)*P*_{xx(t)}+ μ(1 −*P*_{xx(t)})
The second part of the equation denotes the probability that the nucleotide was changed from time 0 and 1, but then got back to its initial states on time 2. The model can be rewritten in a differential equation with the solution; Or if we want to know the probability of nuleotide With time, the probability will approach 0.25 (25%). ## Kimura's two-parameters modelMostly known under the name ## Further Reading- Yang, Z. (2006).
*Computational Molecular Evolution*. Oxford University Press.
## References**^**Jukes, T.H. and Cantor, C.R. (1969). "Evolution of protein molecules", in Munro, H.N. (editor):*Mammalian protein metabolism*. Academic Press, New York, 21-123.**^**Kimura, M. (1980). "A simple method for estimating evolutionary rate of base substitution through comparative studies of nucleotide sequences".*Journal of Molecular Evolution***16**: 111-120.
Categories: Molecular evolution | Phylogenetics |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Models_of_nucleotide_substitution". A list of authors is available in Wikipedia. |