| Highly pathogenic H5N1
| || Countries with poultry or wild birds killed by highly pathogenic H5N1.
| || Countries with human cases of highly pathogenic H5N1.
The global spread of highly pathogenic H5N1 in birds is considered a significant pandemic threat.
While other H5N1 strains are known, they are significantly different from a current, highly pathogenic H5N1 strain on a genetic level, making the global spread of this new strain unprecedented. The H5N1 strain is a fast-mutating, highly pathogenic avian influenza virus (HPAI) found in multiple bird species. It is both epizootic (an epidemic in non-humans) and panzootic (a disease affecting animals of many species especially over a wide area). Unless otherwise indicated, "H5N1" in this article refers to the recent highly pathogenic strain of H5N1.
"Since 1997, studies of H5N1 indicate that these viruses continue to evolve, with changes in antigenicity and internal gene constellations; an expanded host range in avian species and the ability to infect felids; enhanced pathogenicity in experimentally infected mice and ferrets, in which they cause systemic infections; and increased environmental stability." 
Cumulate Human Cases of and Deaths from H5N1
As of April 11 2007
- Source WHO Confirmed Human Cases of H5N1
- "[T]he incidence of human cases peaked, in each of the three years in which cases have occurred, during the period roughly corresponding to winter and spring in the northern hemisphere. If this pattern continues, an upsurge in cases could be anticipated starting in late 2006 or early 2007." Avian influenza – epidemiology of human H5N1 cases reported to WHO
- The regression curve for deaths is y = a + ek x, and is shown extended through the end of April, 2007.
Tens of millions of birds have died of H5N1 influenza and hundreds of millions of birds have been slaughtered and disposed of, to limit the spread of H5N1. Countries that have reported one or more major highly pathogenic H5N1 outbreaks in birds (causing at least thousands but in some cases millions of dead birds) are (in order of first outbreak occurrence): Korea, Vietnam, Japan, Thailand, Cambodia, Laos, Indonesia, China, Malaysia, Russia, Kazakhstan, Mongolia, Turkey, Romania, Croatia, Ukraine, Cyprus, Iraq, Nigeria, Egypt, India, France, Niger, Bosnia, Azerbaijan, Albania, Cameroon, Myanmar, Afghanistan, Israel, Pakistan, Jordan, Burkina Faso, Germany, Sudan, Ivory Coast, Djibouti, Hungary, United Kingdom, Kuwait, Bangladesh, Saudi Arabia, Ghana, Czech Republic, Togo.
Highly pathogenic H5N1 has been found in birds in the wild in numerous other countries: Austria, Bulgaria, Denmark, Greece, Iran, Italy, Poland, Serbia and Montenegro, Slovakia, Slovenia, Spain, Sweden, Switzerland. Surveillance of H5N1 in humans, poultry, wild birds, cats and other animals remains very weak in many parts of Asia and Africa. Much remains unknown about the exact extent of its spread.
H5N1 has low pathogenic varieties endemic in birds in North America. H5N1 has a highly pathogenic variety that is endemic in dozens of species of birds throughout south Asia and is threatening to become endemic in birds in west Asia and Africa. So far, it is very difficult for humans to become infected with H5N1. The presence of highly pathogenic (deadly) H5N1 around the world in both birds in the wild (swans, magpies, ducks, geese, pigeons, eagles, etc.) and in chickens and turkeys on farms has been demonstrated in millions of cases with the virus isolate actually sequenced in hundreds of cases yielding definitive proof of the evolution of this strain of this subtype of the species Influenzavirus A (bird flu virus).
According to Robert Webster:
- "The epicenters of both the Asian influenza pandemic of 1957 and the Hong Kong influenza pandemic of 1968 were in Southeast Asia, and it is in this region that multiple clades of H5N1 influenza virus have already emerged. The Asian H5N1 virus was first detected in Guangdong Province, China, in 1996, when it killed some geese, but it received little attention until it spread through live-poultry markets in Hong Kong to humans in May 1997, killing 6 of 18 infected persons. [...] From 1997 to May 2005, H5N1 viruses were largely confined to Southeast Asia, but after they had infected wild birds in Qinghai Lake, China, they rapidly spread westward. [...] The intermittent spread to humans will continue, and the virus will continue to evolve."Map
Human and bird cases
Confirmed human cases and mortality rate of avian influenza (H5N1)
As of December 28 2007
|| 8|| 5||63%
|| 8|| 5||63%
|| 4|| 4||100%
|| 2|| 2||100%
|| 1|| 1||100%
|| 7|| 7||100%
| PR China
|| 1|| 1||100%
|| 8|| 5||63%
|| 13|| 8||62%
|| 5|| 3||60%
|| 27|| 17||63%
|| 1|| 0||0%
|| 1|| 0||0%
|| 18|| 10||56%
|| 23|| 6||26%
|| 41|| 16||39%
|| 20|| 13||65%
|| 55|| 45||82%
|| 41|| 36||88%
|| 116|| 94||81%
|| 3|| 2||67%
|| 3|| 2||67%
|| 2|| 2||100%
|| 2|| 2||100%
|| 1|| 0||0%
|| 1|| 0||0%
|| 1|| 1||100%
|| 1|| 1||100%
|| 17|| 12||71%
|| 5|| 2||40%
|| 3|| 3||100%
|| 25|| 17||68%
|| 12|| 4||33%
|| 12|| 4||33%
|| 3|| 3||100%
|| 29|| 20||69%
|| 61|| 19||31%
|| 8|| 5||63%
|| 101|| 47||47%
|| 4|| 4||100%
|| 46|| 32||70%
|| 98|| 43||44%
|| 83|| 55||66%
|Source: World Health Organization Communicable Disease Surveillance & Response (CSR)
- A highly pathogenic strain of H5N1 caused flu outbreaks with significant spread to numerous farms, resulting in great economic losses in 1959 in Scotland in chickens and in 1991 in England in turkeys.  These strains were somewhat similar to the current pathogenic strain of H5N1 in two of its ten genes, the gene that causes it to be type H5 and the gene that causes it to be N1. The other genes can and have been reassorted from other subtypes of the bird flu species (their ease at exchanging genes is part of what makes them all one species). Evolution by reassortment of H5N1 from 1999 to 2002 created the Z genotype which became the dominant strain of highly pathogenic H5N1 in 2004 and is now spreading across the entire world in both wild and domestic birds.
- "The precursor of the H5N1 influenza virus that spread to humans in 1997 was first detected in Guangdong, China, in 1996, when it caused a moderate number of deaths in geese and attracted very little attention." 
- In 1997, in Hong Kong, 18 humans were infected and 6 died in the first known case of H5N1 infecting humans. 
- "Human disease associated with influenza A subtype H5N1 re-emerged in January 2003, for the first time since an outbreak in Hong Kong in 1997." Three people in one family were infected after visiting Fujian province in mainland China and 2 died. 
- By midyear of 2003 outbreaks of poultry disease caused by H5N1 occurred in Asia, but were not recognized as such. That December animals in a Thai zoo died after eating infected chicken carcasses. Later that month H5N1 infection was detected in 3 flocks in the Republic of Korea. 
- H5N1 in China in this and later periods is less than fully reported. Blogs have described many discrepancies between official China government announcements concerning H5N1 and what people in China see with their own eyes. Many reports of total H5N1 cases exclude China due to widespread disbelief in China's official numbers. 
In January 2004 a major new outbreak of H5N1 surfaced in Vietnam and Thailand's poultry industry, and within weeks spread to ten countries and regions in Asia, including Indonesia, South Korea, Japan and China. In October 2004 researchers discovered H5N1 is far more dangerous than previously believed because waterfowl, especially ducks, were directly spreading the highly pathogenic strain of H5N1 to chickens, crows, pigeons, and other birds and that it was increasing its ability to infect mammals as well. From this point on, avian influenza experts increasingly refer to containment as a strategy that can delay but not prevent a future avian flu pandemic.
In January 2005 an outbreak of avian influenza affected thirty three out of sixty four cities and provinces in Vietnam, leading to the forced killing of nearly 1.2 million poultry. Up to 140 million birds are believed to have died or been killed because of the outbreak. In April 2005 there begins an unprecedented die-off of over 6,000 migratory birds at Qinghai Lake in central China over three months. This strain of H5N1 is the same strain as is spread west by migratory birds over at least the next ten months. In August 2005 H5N1 spread to Kazakhstan, Mongolia and Russia. On September 29 2005, David Nabarro, the newly appointed Senior United Nations System Coordinator for Avian and Human Influenza, warned the world that an outbreak of avian influenza could kill 5 to 150 million people. David Nabarro later stated that as the virus had spread to migratory birds, an outbreak could start in Africa or the Middle East. Later in 2005 H5N1 spread to Turkey, Romania, Croatia and Kuwait.
- In the first two months of 2006 H5N1 spread to other Asian countries (such as India), north Africa, and Europe in wild bird populations possibly signaling the beginning of H5N1 being endemic in wild migratory bird populations on multiple continents for decades, permanently changing the way poultry are farmed. In addition, the spread of highly pathogenic H5N1 to wild birds, birds in zoos and even sometimes to mammals (example: pet cats) raises many unanswered questions concerning best practices for threat mitigation, trying to balance reducing risks of human and nonhuman deaths from the current nonpandemic strain with reducing possible pandemic deaths by limiting its chances of mutating into a pandemic strain. Not using vaccines can result in the need to kill significant numbers of farm and zoo birds, while using vaccines can increase the chance of a flu pandemic.
- By April 2006 scientists had concluded that containment had failed due to the role of wild birds in transmitting the virus and were now emphasizing far more comprehensive risk mitigation and management measures. 
- In June 2006 WHO predicted an upsurge in human deaths due to H5N1 during late 2006 or early 2007 following a summer/fall lull in most countries, as H5N1 appears to be somewhat seasonal in nature. In July and August 2006 significantly increased numbers of bird deaths due to H5N1 were recorded in Cambodia, China, Laos, Nigeria, and Thailand while continuing unabated a rate unparalleled in Indonesia.
- In September, Egypt and Sudan joined the list of nations seeing a resurgence of bird deaths due to H5N1.
- In November and December, South Korea and Vietnam joined the list of nations seeing a resurgence of bird deaths due to H5N1.
In January, Japan, Hungary, Russia, and the United Kingdom joined the list of nations seeing a resurgence of bird deaths due to H5N1.
In February, Pakistan, Turkey, Afghanistan, and Myanmar joined the list of nations seeing a resurgence of bird deaths due to H5N1; and Kuwait saw its first major outbreak of H5N1 avian influenza.
In March Bangladesh and Saudi Arabia each saw their first major outbreak of H5N1 avian influenza; and Ghana in May.
As H5N1 continued killing many birds and a few people throughout the spring in countries where it is now endemic, in June Malaysia and Germany joined the list of nations seeing a resurgence of bird deaths due to H5N1, while the Czech Republic and Togo saw their first major outbreak of H5N1 avian influenza.
In July France and India joined the list of nations seeing a resurgence of bird deaths due to H5N1.
- January 11, 2007: "South Korean officials say the bird flu virus had been transmitted to a human during a recent outbreak among poultry, but the person showed no symptoms of disease." 
- January 11, 2007: "Bird flu reaches another province in southern Vietnam, spreading to flocks in two new areas in as many days. Some 20 unvaccinated chicks died suddenly over the weekend at a farm in Vinh Long province, and test results came back positive for the lethal H5N1 strain." 
- January 12, 2007: "In Nigeria, a new outbreak of the H5N1 virus is reported in birds in Sokoto and Katsina states." 
- January 14, 2007: "Japanese agricultural officials confirmed yesterday that the virulent H5N1 bird flu virus caused the deaths of thousands of chickens at a poultry farm in southern Japan this week [...] Japan's most recent [prior] outbreak occurred in Kyoto in 2004.".
- January 16, 2007: "A new outbreak of virulent bird flu is confirmed in ducks in northern Thailand -- the first such case in six months. About 100 ducks were reported dead and tested in Phitsanulok province. Wild and free-range ducks within a 3-miles radius are being culled as a precaution." 
- January 17, 2007: Indonesia Works to Stem Bird Flu Cases - Indonesia plans to slaughter hundreds of thousands of backyard chickens over the next few weeks in a bid to stem a surge in human deaths from the H5N1 virus. Indonesia has recorded 61 deaths from bird flu, including four in the last week.
- January 18, 2007: "Mutations in the bird flu virus have been found in two infected people in Egypt, in a form that might be resistant to the medication most commonly used to treat the deadly disease, the WHO said. The mutations in the H5N1 virus strain were not drastic enough to make the virus infectious enough to spark a pandemic, but officials said more such mutations could prompt scientists to rethink current treatment strategies." 
- January 20, 2007: "South Korea prepares to slaughter 273,000 poultry after an H5N1 outbreak at a chicken farm." 
- January 25, 2007: "The European Commission has confirmed the presence of H5N1 in a farm in the southeastern Hungary."
- January 29, 2007:There was an outbreak of H5N1 at three farms or households in the Krasnodar territory, an agricultural region in the southern part of European Russia on the Black Sea, Russian officials said on January 29, 2007.
- February 3, 2007: In late January 2007 there was an outbreak of avian influenza, caused by H5N1, at one of Bernard Matthews' farms in Holton in Suffolk. This infection, the second in the United Kingdom, was confirmed on 3 February 2007. A 3km protection zone, 10km surveillance zone and a restricted zone encompassing 2000Km² were set up and 159,000 turkeys were slaughtered with the cull being completed on 5 February. Around 320 workers at the plant were given anti-viral drugs. The plant was thoroughly disinfected.  with cleaning complete on February 12 and permission being given for production to resume. Neither causation, nor a link with the Bernard Matthews plant in Hungary, has been established but the H5N1 bird flu strains found in geese in Hungary and the turkeys in Britain are 99.96% genetically identical, and almost certainly linked, according to an analysis of the viruses by the Veterinary Laboratories Agency in Weybridge, Surrey.
- February 6, 2007: H5N1 was found in a flock of 40 chickens near Islamabad, Pakistan and all the chickens are now dead from the disease bird flu or culling to prevent its spread.
- February 9, 2007: H5N1 killed 170 chickens in Bogazkoy village, in southeastern Turkey. Nearly 1,000 birds have been culled in Bogazkoy and two nearby villages."
- February 19-20, 2007: "An outbreak of H5N1 detected at two farms near the Laotian capital Vientiane on Feb. 7 was reported." 
- February 22, 2007: "H5N1 is been confirmed in eight suburban Moscow districts, a top Russian veterinary official said, as experts enforced a quarantine in several villages and sought to keep the disease from spreading. The virus, which began killing domestic birds in the Moscow suburbs on Feb. 9, has been traced to a single animal market just outside the capital." 
- February 22, 2007:"Afghan authorities were culling poultry after an outbreak of the deadly H5N1 strain of bird flu in chicken in an eastern Afghan city, a U.N. official said Wednesday."
- February 28, 2007:"Myanmar reported that the H5N1 virus killed poultry at a farm about 5 miles from Rangoon, the country's largest city [...] The outbreak began 2 days ago, killing 68 of 1,360 layer chickens, ducks, and pullets, and officials attributed the outbreak to poor biosecurity on the farm, the report said. The remaining birds were destroyed, and authorities instituted several control measures including limiting poultry movement within the country, screening poultry, and disinfecting the affected area. Myanmar's last poultry outbreak was reported in April 2006." 
- March 5-6, 2007: "China reports bird flu struck a poultry market in the Tibetan capital of Lhasa, prompting the culling of nearly 7,000 birds. The outbreak began March 1." 
- March 22, 2007: Bangladesh saw its first major outbreak of H5N1 avian influenza. "The virus was found in the birds from a poultry firm run by Bangladesh's National Airlines Biman, which has already culled 30,000 birds over the last few days."
- March 23, 2007: "Saudi Arabia's agriculture ministry has said the deadly H5N1 strain of bird flu had been discovered in [...] peacocks, turkeys, ostriches and parrots [and all] birds in the area had been culled. [...] The last reported cases of bird flu in Saudi Arabia involved 37 falcons in 2006. Last month, Saudi Arabia lifted bans going back to 2004 on poultry imports from 42 countries."
- April 6, 2007: "A 13-year-old Cambodian girl dies from bird flu, bringing the country's death toll from the H5N1 virus to seven." 
- May 03, 2007:"Ghana's first case of the highly pathogenic H5N1 bird flu has been confirmed in sick chickens by local laboratories and a US naval laboratory in Egypt, a World Health Organisation official said overnight. Some 1600 birds had already been incinerated as part of efforts to control the outbreak on a farm 20km east of Ghana's capital Accra, near the port of Tema".
- June 05, 2007:" As Bangladesh battles to root out the lethal strain of bird flu known as H5N1 that has spread among its poultry flocks, the ability of the virus to thrive could be aided by the millions of ducks in that country."
- June 06, 2007: Malaysia joined the list of nations seeing a resurgence of bird deaths due to H5N1.
- June 12, 2007: "Indonesia finds traces of H5N1 in apparently healthy-looking poultry, making it tougher to detect the disease in the country hardest hit by the virus, officials said. Sick or dead chickens are used as a sign of H5N1 infection, but the appearance of "asymptomatic" chickens means humans could become more easily infected with bird flu." 
- June 23, 2007: Togo saw its first major outbreak of H5N1 avian influenza. In Germany seven dead wild birds (five swans, one duck, one goose) tested positive for H5N1, the first such cases reported in Germany this year.
- July 6, 2007: "German authorities discover H5N1 in domestic poultry for the first time this year. Officials say a goose in the town of Wickersdorf in the state of Thuringia was found to be infected." 
- July 5, 2007:In July France joined the list of nations seeing a resurgence of bird deaths due to H5N1. Three dead swans in France were found to have the deadly form of H5N1.
- July 26, 2007:In July India joined the list of nations seeing a resurgence of bird deaths due to H5N1. The outbreak was reported in Manipur which borders the country of Myanmar. 132 chickens out of 144 died over a period of six days starting July 7. Over 150,000 birds within a five-km radius of the infected farm "will be culled in the next 10 days."
- August 22, 2007: On August 22, 2007, an Indonesian woman, 28, chicken trader, was the 2nd person to die of bird flu in Bali, raising the death toll in the nation due to the disease to 84 (after 4 days of hospitalization). Tests in 2 local laboratories was positive for the H5N1 strain of the disease. 194 people — the majority of them in Indonesia died since 2003, according to the World Health Organization. 
- September 17, 2007: "In its first H5N1 bird flu outbreak since May, China's Ministry of Agriculture confirmed on its Web site that 36,130 ducks had been culled following the outbreak in Panyu district of the southern metropolis of Guangzhou, not far from Hong Kong." 
- October 8, 2007: "An Indonesian Health Ministry official says a 44-year-old woman has died from bird flu after buying chickens at a local market, lifting the national death toll from the disease to 87." 
- October 25, 2007: "Vietnam reports its third outbreak among poultry this month, this time in the village of Lung Na near the Chinese border. The virus has already struck duck farms in the central province of Quang Tri and Tra Vinh." 
- November 12, 2007: "An outbreak of bird flu in eastern England is the deadly H5N1 strain of the disease. The source of the outbreak had not yet been identified, acting chief veterinarian official Fred Landeg said. Officials said earlier that about 5,000 free-range turkeys, 1,000 ducks and 500 geese on the affected farm would be killed." 
- November 29, 2007: "Authorities continue to conduct tests for bird flu in Romania's eastern Danube Delta, a day after they confirmed an outbreak of the virus in hens and ducks on a small farm in the village of Murighiol, a delta village 155 miles northeast of the capital, Bucharest." 
- December 1, 2007: "Three poultry farms northwest of Warsaw, Poland were cordoned off after the deadly H5N1 strain of bird flu was found in turkeys, officials said on Saturday. The cases were found at farms around the village of Brudzen near the city of Plock. Officials say the virus was most likely brought to Poland by migrating ducks, geese or swans." 
- December 10, 2007: "Chinese health authorities said they were hunting for the causal link between a son and his father both struck by bird flu, but have found no evidence that the virus has mutated into a new strain. The 52-year old father was diagnosed with the H5N1 strain of bird flu late last week in the eastern province of Jiangsu, days after his 24-year old son died from the disease." 
Avian influenza virus H3N2 is endemic in pigs ("swine flu") in China and has been detected in pigs in Vietnam, increasing fears of the emergence of new variant strains. Health experts say pigs can carry human influenza viruses, which can combine (i.e. exchange homologous genome sub-units by genetic reassortment) with H5N1, passing genes and mutating into a form which can pass easily among humans. H3N2 evolved from H2N2 by antigenic shift and caused the Hong Kong Flu pandemic of 1968 and 1969 that killed up to 750,000 humans. The dominant strain of annual flu in humans in January 2006 is H3N2. Measured resistance to the standard antiviral drugs amantadine and rimantadine in H3N2 in humans has increased to 91% in 2005. A combination of these two subtypes of the species known as the avian influenza virus in a country like China is a worst case scenario. In August 2004, researchers in China found H5N1 in pigs. 
In 2005 it was discovered that H5N1 "could be infecting up to half of the pig population in some areas of Indonesia, but without causing symptoms [...] Chairul Nidom, a virologist at Airlangga University's tropical disease center in Surabaya, Java, [Indonesia] was conducting independent research earlier this year. He tested the blood of 10 apparently healthy pigs housed near poultry farms in western Java where avian flu had broken out, Nature reported. Five of the pig samples contained the H5N1 virus. The Indonesian government has since found similar results in the same region, Nature reported. Additional tests of 150 pigs outside the area were negative."
"In Bangkok, Thailand, all the cats in one household are known to have died of H5N1 in 2004. Tigers and leopards in Thai zoos also died, while last year two cats near an outbreak in poultry and people in Iraq were confirmed to have died of H5N1, as were three German cats that ate wild birds. In Austria cats were infected but remained healthy". Cats in Indonesia were also found to have been infected with H5N1.
The spread to more and more types and populations of birds and the ability of felidae (cats) to catch H5N1 from eating this natural prey means the creation of a reservoir for H5N1 in cats where the virus can adapt to mammals is one of the many possible pathways to a pandemic.
Variants have been found in a number of domestic cats, leopards and tigers in Thailand, with high lethality.  "The Thailand Zoo tiger outbreak killed more than 140 tigers, causing health officials to make the decision to cull all the sick tigers in an effort to stop the zoo from becoming a reservoir for H5N1 influenza (ProMED-mail, 2004i; ProMED-mail, 2004w). A study of domestic cats showed H5N1 virus infection by ingestion of infected poultry and also by contact with other infected cats (Kuiken et al., 2004)."  The initial OIE report reads: "the clinical manifestations began on 11 October 2004 with weakness, lethargy, respiratory distress and high fever (about 41-42 degrees Celsius). There was no response to any antibiotic treatment. Death occurred within three days following the onset of clinical signs with severe pulmonary lesions." 
February 28, 2006
A dead cat infected with the H5N1 bird flu virus was found in Germany. 
March 6, 2006
Hans Seitinger, the top agriculture official in the southern state of Styria, Austria announced that several still living cats in Styria have tested positive for H5N1: 
It was announced in the August 2006 CDC EID journal that while literature describing HPAI H5N1 infection in cats had been limited to a subset of clade I viruses; a Qinghai-like virus (they are genetically distinct from other clade II viruses) killed up to five cats and 51 chickens from February 3 to February 5, 2006 in Grd Jotyar (~10 km north of Erbil City, Iraq). Two of the cats were available for examination.
- "An influenza A H5 virus was present in multiple organs in all species from the outbreak site in Grd Jotyar (Table). cDNA for sequencing was amplified directly from RNA extracts from pathologic materials without virus isolation. On the basis of sequence analysis of the full HA1 gene and 219 amino acids of the HA2 gene, the viruses from the goose and 1 cat from Grd Jotyar and from the person who died from Sarcapcarn (sequence derived from PCR amplification from first-passage egg material) are >99% identical at the nucleotide and amino acid levels (GenBank nos. DQ435200–02). Thus, no indication of virus adaptation to cats was found. The viruses from Iraq are most closely related to currently circulating Qinghai-like viruses, but when compared with A/bar-headed goose/Qinghai/65/2005 (H5N1) (GenBank no. DQ095622), they share only 97.4% identity at the nucleic acid level with 3 amino acid substitutions of unknown significance. On the other hand, the virus from the cat is only 93.4% identical to A/tiger/Thailand/CU-T4/2004(H5N1) (GenBank no. AY972539). These results are not surprising, given that these strains are representative of different clades (8,9). Sequencing of 1,349 bp of the N gene from cat 1 and the goose (to be submitted to GenBank) show identity at the amino acid level, and that the N genes of viruses infecting the cat and goose are >99% identical to that of A/bar-headed goose/Qinghai/65/2005(H5N1). These findings support the notion that cats may be broadly susceptible to circulating H5N1 viruses and thus may play a role in reassortment, antigenic drift, and transmission."
January 24, 2007
"Chairul Anwar Nidom of Airlangga University in Surabaya, Indonesia, told journalists last week that he had taken blood samples from 500 stray cats near poultry markets in four areas of Java, including the capital, Jakarta, and one area in Sumatra, all of which have recently had outbreaks of H5N1 in poultry and people. Of these cats, 20 per cent carried antibodies to H5N1. This does not mean that they were still carrying the virus, only that they had been infected - probably through eating birds that had H5N1. Many other cats that were infected are likely to have died from the resulting illness, so many more than 20 per cent of the original cat populations may have acquired H5N1."
Mammals in general
H5N1 has been transmitted in laboratories to many species including mice and ferrets to study its effects.
H5N1 was transmitted in the wild to three civet cats in Vietnam in August 2005 and a stone marten in Germany in March 2006. 
The BBC reported that a stray dog in Azerbaijan died from the disease on March 15 2006. 
Experts believe more work is needed to determine the role of mammals in the epidemiology of H5N1. Officials are not doing enough to monitor cats, dogs and other carnivores for their possible role in transmitting H5N1. People living in areas where the A(H5N1) virus has infected birds are advised to keep their cats indoors. "Cats can be infected through the respiratory tract. Cats can also be infected when they ingest the virus, which is a novel route for influenza transmission in mammals. But cats excrete only one-thousandth the amount of virus that chickens do [...] The concern is that if large numbers of felines and other carnivores become infected, the virus might mutate in a series of events that could lead to an epidemic among humans. Dogs, foxes, seals and other carnivores may be vulnerable to A(H5N1) virus infection, Dr. Osterhaus said. Tests in Thailand have shown that the virus has infected dogs without causing apparent symptoms." 
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- ^ WHO (March 2, 2004). "Situation (poultry) in Asia: need for a long-term response, comparison with previous outbreaks". Disease Outbreak News: Avian influenza A(H5N1) 31.
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- ^ WHO. Confirmed Human Cases of Avian Influenza A(H5N1).
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Officials confirm H5N1 virus at Japanese farm - Taipei Times, January 14, 2007
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outbreak of 2007 published January 29, 2007
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- ^ "Clean-up begins at bird flu farm", BBC News, 06 February 2007
- ^ "Farm hit by bird-flu to reopen", Natalie Paris, Daily Telegraph, 12 December 2007
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confirm bird flu link to Hungary"], John Vidal, The Guardian, 14 February 2007
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Star Publications (Malaysia) article Bangladesh says detects bird flu in poultry published March 23, 2007
Reuters article Saudi Arabia reports bird flu outbreak published March 23, 2007
- ^ a b c d e f g h i j CBS News: Bird flu soars
The Australian article First H5N1 case in Ghana confirmed published May 03, 2007
- ^ The Hindu article Bangladesh
fighting to contain bird flu published June 05, 2007
- ^ The Star article Bird flu detected, culling begins published June 06, 2007 Fox News
article Bird Flu Makes a Comeback in Malaysia published June 06, 2007
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Expatica Communications article Bird flu outbreak confirmed in France published July 5, 2007
Times of India article Govt confirms bird flu outbreak in Manipur published July 26, 2007
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- ^ CIDRAP article Indonesian pigs have avian flu virus; bird cases double in China published May 27, 2005
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